Fig. 1.

Adipocyte raptor deletion reduces adiposity and promotes hepatic steatosis and insulin resistance in mice. Adipose tissue mTORC1 and mTORC2 signaling (A); body weight gain (B); epididymal (C), retroperitoneal (D), and liver mass (E); liver triacylglycerol (TAG) content (F); fasting glucose (G), and insulin (H); GTT (I), and area under the curve (AUC) (J); ITT and rates of glucose disappearance (kITT) (K, L); and liver mRNA levels of PEPCK (M) and G6Pase (N) in RapWT and RapKO mice fed with chow or HFD for 8 weeks. Values are mean ± SEM of 6–12 mice. Means not sharing a common superscript are significantly different from each other, P < 0.05.