Fig. 4.

NAC attenuates adipose tissue inflammation induced by adipocyte raptor deletion. Adipose tissue mRNA levels of oxidative stress markers (A) and UCP1 (B); protein content of UCP1 (C); mRNA levels of macrophage markers (D); CLS density (E); mRNA levels of NLRP3-inflammasome components (F); IL-1β content (G) (ELISA); and pro-IL-1β and mature IL-1β protein contents (H, I) (Western) in chow-fed RapWT and RapKO mice treated with vehicle (VEH) or NAC (300 mg/kg) by gavage for 7 days. Values are mean ± SEM of four to eight mice. Means not sharing a common superscript are significantly different from each other, P < 0.05.