TABLE 3.
Liver BAs in OPN-KO and WT mice
Species | WT | OPN-KO | |
BA | TOTAL | 396.57 ± 58.96 | 304.99 ± 31.64 |
Tauroconjugated BA | TOTAL | 338.58 ± 55.43 | 266.35 ± 29.40 |
TαMCA | 12.80 ± 3.02 | 12.36 ± 1.41 | |
TβMCA | 94.98 ± 19.6 | 76.96 ± 10.77 | |
TUDCA | 6.86 ± 1.29 | 6.59 ± 0.82 | |
THCA | 0.06 ± 0.04 | 0.07 ± 0.02 | |
THDCA | 2.44 ± 0.51 | 2.61 ± 0.36 | |
TCA | 201.2 ± 30.45 | 146.35 ± 15.29 | |
TCDCA | 8.13 ± 1.43 | 6.90 ± 1.02 | |
TDCA | 11.83 ± 1.26 | 14.23 ± 1.60 | |
TLCA | 0.28 ± 0.04 | 0.29 ± 0.05 | |
Glycoconjugated BA | TOTAL | 0.54 ± 0.09 | 0.26 ± 0.05a |
GUDCA | 0.01 ± 0.002 | 0.003 ± 0.001a | |
GCA | 0.52 ± 0.09 | 0.24 ± 0.04a | |
GCDCA | 0.003 ± 0.002 | 0.002 ± 0.001 | |
GDCA | 0.01 ± 0.01 | 0.007 ± 0.003 | |
Free BA | TOTAL | 57.4 ± 8.70 | 38.4 ± 6.21 |
UDCA | 9.92 ± 1.51 | 6.57 ± 0.97 | |
αMCA | 13.32 ± 2.24 | 8.10 ± 1.16a | |
βMCA | 19.80 ± 2.80 | 10.97 ± 1.77a | |
CA | 12.91 ± 2.95 | 11.54 ± 2.86 | |
CDCA | 0.57 ± 0.1 | 0.47 ± 0.08 | |
DCA | 0.18 ± 0.04 | 0.17 ± 0.02 | |
HDCA | 0.70 ± 0.05 | 0.52 ± 0.07a | |
LCA | 0.04 ± 0.01 | 0.04 ± 0.01 | |
Secondary BA | TOTAL | 13.04 ± 1.3 | 15.24 ± 1.6 |
Values are mean ± SEM from eight animals per group and are expressed in nanomoles per gram of liver. CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; GUDCA, glycoursodeoxycholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; TCA, taurocholic acid; TCDCA, taurochenodeoxycholic acid; TDCA, taurodeoxycholic acid; THCA, taurohyocholic acid; THDCA, taurohyodeoxycholic acid; TLCA, taurolithocholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro-α-muricholic acid; TβMCA, tauro-β-muricholic acid; UDCA, ursodeoxycholic acid; αMCA, α-muricholic acid; βMCA, β-muricholic acid.
P < 0.05, significant difference between OPN-KO and WT mice.