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. 2017 Jul 28;58(9):1903–1915. doi: 10.1194/jlr.M078980

TABLE 3.

Liver BAs in OPN-KO and WT mice

Species WT OPN-KO
BA TOTAL 396.57 ± 58.96 304.99 ± 31.64
Tauroconjugated BA TOTAL 338.58 ± 55.43 266.35 ± 29.40
TαMCA 12.80 ± 3.02 12.36 ± 1.41
TβMCA 94.98 ± 19.6 76.96 ± 10.77
TUDCA 6.86 ± 1.29 6.59 ± 0.82
THCA 0.06 ± 0.04 0.07 ± 0.02
THDCA 2.44 ± 0.51 2.61 ± 0.36
TCA 201.2 ± 30.45 146.35 ± 15.29
TCDCA 8.13 ± 1.43 6.90 ± 1.02
TDCA 11.83 ± 1.26 14.23 ± 1.60
TLCA 0.28 ± 0.04 0.29 ± 0.05
Glycoconjugated BA TOTAL 0.54 ± 0.09 0.26 ± 0.05a
GUDCA 0.01 ± 0.002 0.003 ± 0.001a
GCA 0.52 ± 0.09 0.24 ± 0.04a
GCDCA 0.003 ± 0.002 0.002 ± 0.001
GDCA 0.01 ± 0.01 0.007 ± 0.003
Free BA TOTAL 57.4 ± 8.70 38.4 ± 6.21
UDCA 9.92 ± 1.51 6.57 ± 0.97
αMCA 13.32 ± 2.24 8.10 ± 1.16a
βMCA 19.80 ± 2.80 10.97 ± 1.77a
CA 12.91 ± 2.95 11.54 ± 2.86
CDCA 0.57 ± 0.1 0.47 ± 0.08
DCA 0.18 ± 0.04 0.17 ± 0.02
HDCA 0.70 ± 0.05 0.52 ± 0.07a
LCA 0.04 ± 0.01 0.04 ± 0.01
Secondary BA TOTAL 13.04 ± 1.3 15.24 ± 1.6

Values are mean ± SEM from eight animals per group and are expressed in nanomoles per gram of liver. CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; GUDCA, glycoursodeoxycholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; TCA, taurocholic acid; TCDCA, taurochenodeoxycholic acid; TDCA, taurodeoxycholic acid; THCA, taurohyocholic acid; THDCA, taurohyodeoxycholic acid; TLCA, taurolithocholic acid; TUDCA, tauroursodeoxycholic acid; TαMCA, tauro-α-muricholic acid; TβMCA, tauro-β-muricholic acid; UDCA, ursodeoxycholic acid; αMCA, α-muricholic acid; βMCA, β-muricholic acid.

a

P < 0.05, significant difference between OPN-KO and WT mice.