Skip to main content
. 2017 Sep 1;12(9):e0182397. doi: 10.1371/journal.pone.0182397

Table 2. Multivariable cox proportional hazards analysis of clinicopathologic factors associated with survival, stratified by histology types.

ILC (n = 85,048) IDC (n = 711,287)
Factor HR P 95% CI HR P 95% CI
Age at diagnosis, years
 <40 Referent Referent
 40–60 NS 0.64 1.42 1.20 <0.0001 1.09 1.31
 >60 NS 1.00 2.19 2.92 <0.0001 2.67 3.19
Marital status
 Single Referent Referent
 Married 0.71 <0.0001a 0.64 0.80 0.63 <0.0001a 0.61 0.65
Tumor site(s)
 Only one site(left or right) Referent Referent
 Two or more sites NS 0.46 1.20 NS 0.57 1.04
Tumor size, mm
 < = 20 Referent Referent
 21–40 1.37 <0.0001c 1.19 1.59 1.45 <0.0001c 1.39 1.51
 > = 41 1.28 <0.0001c 1.09 1.51 1.49 <0.0001c 1.41 1.57
Tumor stage
 I-II Referent Referent
 III-IV 1.79 <0.0001c 1.41 2.29 1.16 0.001c 1.06 1.26
Tumor grade
 I Referent Referent
 II 1.34 <0.0001a 1.17 1.54 1.16 <0.0001a 1.10 1.21
 III 1.83 <0.0001a 1.53 2.17 1.58 <0.0001a 1.51 1.67
 Undifferentiated NSa 0.75 4.45 1.75 <0.0001a 1.45 2.11
Breast–AdjustedAJCC 6th T
 T0 Referent Referent
 Tis NSa 0.08 1.68 NSa 0.54 2.76
 T1-2 NSa 0.01 2.18 3.43 0.005a 1.45 8.13
 T3-4 NSa 0.34 7.07 4.17 0.001a 1.85 9.44
 Any T,Mets NSa 0.15 3.81 NSa 0.71 4.16
Breast–AdjustedAJCC 6th N
 N0 Referent Referent
 N1 NSa 0.77 1.14 0.87 <0.0001 0.81 0.93
 N2 NSa 0.69 1.26 0.89 0.023 0.80 0.98
 N3 NSa 0.80 1.22 NSa 0.95 1.12
 NX NSa 0.73 1.16 1.12 0.032 1.01 1.24
Lymph node, positive counts
 Negative Referent Referent
 1–3 2.50 <0.0001a 1.19 3.27 1.62 <0.0001a 1.50 1.76
 4–10 3.95 <0.0001a 2.78 5.61 2.38 <0.0001a 2.15 2.65
 >10 5.98 <0.0001a 4.35 7.98 3.11 <0.0001a 2.78 3.46
 Positive, counts unknown 4.68 <0.0001a 3.39 6.48 2.10 <0.0001a 1.89 2.34
 No examined nodes 6.95 <0.0001a 3.46 13.9 3.12 <0.0001a 2.50 3.91
Breast–AdjustedAJCC 6th M
 M0 Referent Referent
 M1 3.11 <0.0001 2.62 3.71 2.68 <0.0001 2.55 2.83
 MX NS 0.93 1.97 NS 0.93 1.14
ER status
 Positive Referent Referent
 Negative 2.14 <0.0001a 1.82 2.52 1.87 <0.0001a 1.82 1.92
 Borderline 5.24 <0.0001a 1.95 14.1 1.93 <0.0001a 1.48 2.52
PR status
 Positive Referent Referent
 Negative 2.08 <0.0001a 1.89 2.29 1.70 <0.0001a 1.65 1.74
 Borderline 2.51 <0.0001a 1.51 4.20 1.28 0.007a 1.07 54
ER/PR status
 ER+/PR+ Referent Referent
 ER+/PR- 1.98 <0.0001b 1.79 2.20 1.37 <0.0001b 1.32 1.43
 ER-/PR+ 2.55 <0.0001b 1.52 4.29 2.02 <0.0001b 1.47 2.23
 ER-/PR- 1.95 <0.0001b 1.81 2.11 1.79 <0.0001b 1.76 1.83
Cancer directed surgery
 Not performed Referent Referent
 Performed 0.16 <0.0001a 0.15 0.17 0.17 <0.0001a 0.17 0.17
Surgery category
 Mastectomy Referent Referent
 Breast conserving surgery 0.69 <0.0001a 0.66 0.71 0.63 <0.0001a 0.62 0.64
Radiation
 Not performed Referent Referent
 Performed 0.73 <0.0001a 0.65 0.82 0.58 <0.0001a 0.56 0.60

HR, hazard ratio; CI, confidence interval; NS, not significant; ILC, invasive lobular carcinoma; IDC, invasiveductal carcinoma;ER, estrogen receptor; PR, progesterone receptor; -,negative; +, positive; NS, not significant.

a Calculated after exclusion of patients in the Unknown category;

b Calculated after exclusion of patients in the Borderline or Unknown category.

cCalculated after exclusion of patients in the no tumor, stage 0 or Unknown category.