Table 2.

Cogstate assessment schedule during ALL therapy

	Cognitive Assessment and Medical Therapy Schedule	Notable CNS-toxic therapy
C1	Less than 4 weeks from the start of therapy
C2	Week 3 of Consolidation 1	High-dose intravenous methotrexate
C3	Week 3 of CNS phase	4 doses of intrathecal chemotherapy within 2 weeks
C4	In Consolidation 2; week 3 of a cycle
C5	In Continuation, approximately 15 months post-diagnosis; week 3 of a cycle
C6	1 year after completion of protocol therapy

D DNA collection, F CSF collection, C Cogstate testing