Table 1.
Patient Characteristics
| ID | Indications for HCT | Age at HCT, yr | Donor Source | Initial HCT LOS, d | % Whole Blood Chimerism (Days 100, 180, 365 after HCT) | No. of Transfusions through Day 100 after HCT (Platelet/PRBC) | GVHD | Disease Status at 1 Year | No. of Readmissions in First 100 Days after HCT | Post-HCT Complications | Lansky/Karnofsky Performance Scores (Before HCT, 1 Year after HCT) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Dactylitis, ACS, VOC | 5.3 | RCB | 78 | 95,97,94 | 17/10 | No | NED | 1 | None | 90/no note |
| 2 | ACS | 7.3 | RBM | 38 | 91,93,93 | 12/6 | No | NED | 3 | None | 100/90 |
| 3 | VOC | 9.9 | UCB | 57 | 99,99,98 | 23/10 | Yes-acute | NED | 2 | None | 100/90 |
| 4 | VOC | 5.3 | RBM | 43 | 98,96,93 | 6/1 | No | NED | 0 | None | 100/90 |
| 5 | VOC | 7.0 | RBM | 42 | 90,88,80 | 0/0 | No | NED | 1 | None | 100/100 |
| 6 | Abnormal TCD, ACS | 6.3 | UCB | 66 | 60,94,93 | 14/7 | Yes-acute and chronic | NED | 0 | Stroke | 90/100 |
| 7 | Splenic sequestration, dactylitis | 2.7 | RCB | 105 | 65,88,89 | 43/14 | No | NED | 4 | None | 100/no note |
| 8 | ACS | 6.3 | UCB | 114 | 0, not evaluable, not evaluable | 95/19 | Yes-acute | NR | 0 | None | 90/90 |
| 9 | VOC, splenic sequestration | 2.4 | UCB | 162 | 99,96,99 | 40/12 | No | NED | 0 | None | 100/100 |
| 10 | VOC, ACS | 2.3 | RBM | 37 | 96,95,94 | 9/3 | No | NED | 0 | None | 100/100 |
| 11 | Sickle retinopathy, VOC, ACS, splenic sequestration | 18.3 | RBM | 37 | 99,96,94 | 3/3 | No | NED | 1 | None | 100/90 |
| 12 | VOC, ACS, splenic sequestration | 9.4 | RBM | 57 | 92,94,78 | 31/10 | Yes-acute | NED | 1 | None | 100/80 |
| 13 | Abnormal TCD | 5.4 | RBM | 44 | 89,79,75 | 15/8 | No | NED | 1 | None | 100/100 |
| 14 | Stroke, splenic sequestration | 20.2 | RBM | 37 | 98,90,83 | 2/1 | No | NED | 1 | None | 80/90 |
| 15 | VOC, ACS | 14.7 | RBM | 46 | 98,89,86 | 4/1 | No | NED | 0 | None | 90/100 |
| 16 | ACS, VOC | 13.8 | RBM | 65 | 99,98,94 | 24/6 | Yes-acute | NED | 1 | None | 100/no note |
| 17 | VOC | 12.4 | RBM | 70 | 99,98,97 | 2/4 | No | NED | 0 | None | 100/100 |
| 18 | Splenic sequestration | 4.5 | UCB | 57 | 85,91,91 | 19/11 | No | NED | 1 | None | 100/no note |
| 19 | Splenic sequestration, ACS, VOC | 16.3 | RBM | 30 | 99,98,92 | 1/4 | No | NED | 1 | None | 100/100 |
| 20 | Abnormal TCD, Silent stroke, ACS, VOC | 8.3 | RBM | 30 | 38,58,68 | 16/5 | No | NED | 2 | Stroke | 100/100 |
| 21 | ACS | 12.4 | RBM | 29 | 89,87,93 | 2/1 | No | NED | 0 | PRES | 100/100 |
| 22 | ACS, splenic sequestration | 13.3 | RBM | 55 | 99,83,77 | 11/7 | No | NED | 0 | Diarrhea, hypomagnesia, grade II mucositis, E. Cloace sepsis, Acinetobactor line infection, VZV | 100/80 |
| 23* | Had no SCD-related complications, had matched sibling | 2.7 | Sibling bone marrow | 40 | 100 | 16/7 | No | 0 | Diarrhea, hypomagnesia, grade II mucositis, E. Cloace sepsis, Acinetobactor line infection, VZV | 100 |
LOS indicates length of stay; ACS, acute chest syndrome; RCB, related cord blood; NED, no evidence of disease; RBM, related bone marrow; UCB, unrelated cord blood; NR, no response; TCD, transcranial Doppler; PRES, posterior reversible encephalopathic syndrome; VZV, varicella zoster virus.
*
Patient not yet 1 year after HCT.