Table 1.

Total ocular GVHD Score incorporates all clinical, eGFP, and MGI scoring parameters encompassing both the lid margin scoring index and cornea scoring index to generate a total ocular GVHD score with a maximum value of 24. The level of scores obtained were compared with total systemic GVHD scores to monitor overall disease progression.

Ocular criteria and scoring system used to assess pre-clinical model with ocular graft vs. host disease
Total Ocular GVHD Score	Grade 0	Grade 1	Grade 2	Grade 3	Grade 4
Clinical Lid Margin	Clear	Mild lid edema	Edema and partial lid closure	Edema, partial lid closure, skin swelling	Full lid closure
Lid Margin eGFP	Clear	Minimal eGFP infiltrate: upper/lower lid	eGFP infiltrate: upper/lower lid	eGFP infiltrate both lids & 0–1mm skin involvement	eGFP infiltrate both lids & 1mm skin involvement
MGI Lid Margin	0–25	25–50	50–75	75–100	>100
Clinical Cornea	Clear	Epithelial haze	Diffuse keratopathy, pupil visualized	Confluent keratopathy, pupil not visualized	Ulceration
Cornea eGFP	Clear	eGFP infiltrate: 25%cornea / limbus	eGFP infiltrate: 50%cornea / limbus	Diffuse eGFP infiltrate: 100% cornea	Confluent eGFP infiltrate: 100% cornea
MGI Cornea	0–25	25–50	50–75	75–100	>100