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. 2017 Jul 6;8(32):52026–52044. doi: 10.18632/oncotarget.19036

Figure 1. Effects of midostaurin, R406, R788, and PRT062607 on inhibition of proliferation of Ba/F3 cells expressing constitutively activated TEL-SYK or constitutively activated SYK-TEL.

Figure 1

A.-D. Three-day treatment of Ba/F3-TEL-SYK cells with midostaurin (A), R406 (B), R788 (C), or PRT062607 (D) in the presence and absence of 20% WEHI (used as a source of IL-3). E.-H. Three-day treatment of Ba/F3-SYK-TEL cells with midostaurin (E), R406 (F), R788 (G), or PRT062607 (H). Error bars represent the mean+/−S.D. for all proliferation studies. I.-K. Effects of midostaurin on apoptosis (annexin/pi measurement) in cells expressing active SYK. Error bars represent the mean+/−S.D. L. Effects of midostaurin on apoptosis (caspase 3/7 measurement) in cells expressing active SYK. Error bars represent the mean+/−S.D.