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. 2016 Jul 16;8(32):52104–52117. doi: 10.18632/oncotarget.10631

Figure 3. Demethylation of E2BS 3 and 4 in the HPV 16 URR of CaSki and UM-SCC-47 cells after DAC treatment.

Figure 3

(A) Schematic illustration of the HPV 16 genome and the URR highlighting E2BS 3 and 4. CpG methylation levels of E2BS 3 (B) and 4 (C) in CaSki, SiHa, UM-SCC-47 and UM-SCC-104 after treatment with DAC. The results are presented as mean methylation levels of the two CpG dinucleotides located in E2BS 3 (nucleotide position: 37 and 43) and in E2BS 4 (nucleotide position: 52 and 58) as obtained by pyrosequencing. Error bars represent the standard deviation of the mean methylation level.