Figure 6. Knockdown of ALDH3A1 expression in HNSCC cells increases sensitivity to cisplatin.

(A) Knockdown of ALDH3A1 by lentiviral transduction of shRNA in SCC4 cells was confirmed by Western blot assay. (B) Wild type (WT) and ALDH3A1 knockdown cells were treated with cisplatin on days 1 and 2, and cell viability was quantified by MTT on the fourth day. Results were expressed as percent of control (*p < 0.05 vs. cisplatin treated control, t-test).