Table 2. Univariate and multivariate analyses of prognostic factors with TTR and OS in HCC (n = 323).
| Variables | TTR | OS | ||
|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | |
| Univariate analysis | ||||
| Age, years (≤50 vs. >50) | 1.023 (0.760-1.377) | 0.879 | 0.828 (0.610–1.125) | 0.228 |
| Sex (female vs. male) | 1.863 (1.143–3.036) | 0.013 | 1.757 (1.049–2.942) | 0.032 |
| HBsAg (negative vs. positive) | 1.007 (0.659–1.538) | 0.974 | 1.039 (0.669–1.614) | 0.866 |
| AFP, ng/mL (≤20 vs. >20) | 1.155 (0.835–1.597) | 0.385 | 1.548 (1.083–2.211) | 0.016 |
| γ-GT, U/L (≤54 vs. >54) | 1.329 (0.978–1.805) | 0.069 | 1.737 (1.253–2.409) | 0.001 |
| Liver cirrhosis (no vs. yes) | 1.102 (0.677–1.795) | 0.696 | 1.308 (0.769–2.224) | 0.332 |
| Tumor size, cm (≤5 vs. >5) | 1.817 (1.346–2.452) | 0.000 | 2.482 (1.806–3.412) | 0.000 |
| Tumor number (single vs. multiple) | 1.362 (0.907–2.044) | 0.136 | 1.517 (1.025–2.243) | 0.037 |
| Microvascular invasion (no vs. yes) | 1.915 (1.420–2.583) | 0.000 | 2.479 (1.815–3.388) | 0.000 |
| Tumor encapsulation (complete vs. none) | 1.679 (1.246–2.263) | 0.001 | 1.715 (1.260–2.336) | 0.001 |
| Tumor differentiation (I+II vs. II+IV) | 1.238 (0.870–1.763) | 0.236 | 1.581 (1.119–2.233) | 0.009 |
| TNM stage (I vs. II III) | 2.072 (1.527–2.814) | 0.000 | 2.683 (1.935–3.720) | 0.000 |
| PDEF (low vs. high) | 0.705 (0.523–0.949) | 0.021 | 0.510 (0.374–0.697) | 0.000 |
| Multivariate analysis | ||||
| Sex (female vs. male) | 1.692 (1.029-2.781) | 0.038 | 1.426 (0.848-2.404) | 0.183 |
| AFP, ng/mL (≤20 vs. >20) | 1.039 (0.740-1.459) | 0.826 | 1.143 (0.784-1.665) | 0.488 |
| γ-GT, U/L (≤54 vs. >54) | 1.158(0.838-1.599) | 0.373 | 1.427 (1.009-2.018) | 0.044 |
| Tumor size, cm (≤5 vs. >5) | 1.531(1.112-2.108) | 0.009 | 1.933 (1.381-2.705) | 0.000 |
| Tumor number (single vs. multiple) | 1.252(0.824-1.901) | 0.290 | 1.341 (0.896-2.006) | 0.153 |
| Microvascular invasion (no vs. yes) | 1.537(1.113-2.122) | 0.009 | 1.926 (1.383-2.683) | 0.000 |
| Tumor encapsulation (complete vs. none) | 1.578(1.158-2.148) | 0.004 | 1.578 (1.143-2.180) | 0.006 |
| Tumor differentiation (I+II vs. II+IV) | 1.192(0.823-1,727) | 0.351 | 1.482 (1.031-2.129) | 0.033 |
| PDEF (low vs. high) | 0.776(0.468-0.860) | 0.101 | 0.584 (0.424-0.804) | 0.001 |
TTR: time to recurrence; OS: overall survival; HBsAg: hepatitis B surface antigen; AFP: a-fetoprotein; γ-GT: γ-glutamyl transferase; TNM: tumor-nodes metastasis; HR: hazard ratio; CI: confidential interval.