Table 3. Result in the FDG parameters.
| FDG-PET Parameter | Mean ± SD All |
EGFR mutations | P value | KRAS mutations | P value | ||
|---|---|---|---|---|---|---|---|
| (+) | (−) | (+) | (−) | ||||
| Metabolic tumor diameter (mm) | 33 ± 27 (8–230) |
27 ± 13 (8–53) |
34 ± 30 (8–230) |
0.60 | 36 ± 29 (8–135) |
32 ± 27 (8–230) |
0.75 |
| SUVmax | 6.3 ± 5.9 (0.7–36.7) |
4.2 ± 3.8 (0.7–14.2) |
6.9 ± 3.8 (0.8–36.7) |
0.009 | 7.4 ± 7.6 (0.9–36.7) |
5.9 ± 5.3 (0.7–29.6) |
0.38 |
| SUVmean | 3.8 ± 2.7 (0.7–18.9) |
3.1 ± 2.3 (0.8–10.0) |
4.0 ± 2.9 (0.7–18.9) |
0.09 | 4.2 ± 3.6 (0.7–18.9) |
6.9 ± 3.8 (0.8–36.7) |
0.67 |
| TLG | 109.2 ± 530.8 (0.4–5577.5) |
17.6 ± 34.7 (0.4–162.3) |
143.4 ± 623.5 (0.5–5577.5) |
0.04 | 269.4 ± 1028.1 (0.7–5577.5) |
61.4 ± 203.9 (0.4–1725.8) |
0.45 |
| MTV | 14.5 ± 38.8 (0.3–295.1) |
6.2 ± 10.4 (0.3–50.8) |
17.6 ± 45.0 (0.3–295.1) |
0.29 | 24.9 ± 65.8 (0.7–295.1) |
11.2 ± 25.2 (0.3–137.9) |
0.59 |
| SD (>1cm) | 1.20 ± 1.16 (0.08–6.07) |
0.90 ± 1.17 (0.11–5.87) |
1.27 ± 1.17 (0.08–6.07) |
0.02 | 1.30 ± 1.30 (0.08–6.07) |
1.16 ± 1.13 (0.11–5.96) |
0.65 |
| 1/COV (> 1cm) | 4.24 ± 2.01 (1.51–17.91) |
5.10 ± 1.89 (1.70–9.09) |
4.13 ± 2.34 (1.51–17.91) |
0.003 | 4.35 ± 2.49 (1.70–15.13) |
4.34 ± 2.21 (1.51–17.91) |
0.75 |
| AUC (> 1cm) | 0.61 ± 0.12 (0.28–0.86) |
0.66 ± 0.12 (0.33–0.81) |
0.60 ± 0.12 (0.28– 0.86) |
0.02 | 0.61 ± 0.12 (0.28–0.78) |
0.61 ± 0.13 (0.33–0.86) |
0.96 |
| SD (> 2cm) | 1.35 ± 1.25 (0.09–6.07) |
0.95 ± 1.23 (0.11–5.87) |
1.52 ± 1.25 (0.09–6.07) |
0.006 | 1.45 ± 1.37 (0.09–6.07) |
1.33 ± 1.23 (0.11–5.96) |
0.76 |
| 1/COV (> 2cm) | 3.96 ± 1.53 (1.51–8.93) |
4.93 ± 1.81 (0.33–8.93) |
3.59 ± 1.25 (1.51–7.67) |
0.001 | 3.85 ± 1.36 (1.69–7.67) |
3.98 ± 1.61 (1.51–8.93) |
0.98 |
| AUC (> 2cm) | 0.59 ± 0.12 (0.28–0.81) |
0.66 ± 0.12 (0.33–0.81) |
0.57 ± 0.12 (0.28– 0.78) |
0.007 | 0.61 ± 0.12 (0.28– 0.78) |
0.58 ± 0.13 (0.33– 0.81) |
0.37 |
| SD (> 3cm) | 1.71 ± 1.39 (0.09–6.07) |
1.39 ± 1.58 (0.09–6.07) |
1.83 ± 1.58 (0.09–6.07) |
0.11 | 1.92 ± 1.69 (0.09–6.07) |
1.71 ± 1.33 (0.19–5.96) |
0.72 |
| 1/COV (> 3cm) | 3.45 ± 1.48 (1.50–8.92) |
4.03 ± 1.73 (1.70–7.42) |
3.10 ± 1.07 (1.51–7.67) |
0.12 | 3.55 ± 1.55 (1.70–7.67) |
3.25 ± 1.23 (1.51–7.42) |
0.38 |
| AUC (> 3cm) | 0.53 ± 0.12 (0.28–0.78) |
0.57 ± 0.12 (0.33– 0.78) |
0.51 ± 0.11 (0.28– 0.78) |
0.08 | 0.54 ± 0.14 (0.28–0.78) |
0.52 ± 0.11 (0.33– 0.77) |
0.68 |
SUV: Standardized uptake value, SUVmax: Maximum SUV, TLG: Total lesion glycolysis, MTV: Metabolic tumor volume. SD: standard deviation, COV: coefficient of variation, AUC: area under the curve of the cumulative SUV-volume histogram, range shown in parenthesis.