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. 2017 May 19;8(32):52995–53016. doi: 10.18632/oncotarget.18031

Figure 2. idiopathic and heritable PAH patients do not have a distinct endothelial methylation-based signature.

Figure 2

(A) Idiopathic PAH patients are represented in light blue and heritable PAH patients in dark blue. On the heatmap, the over- and under- expressed promoters are in red and green, respectively. Only three promoters displayed a differential methylation status, and only one is upstream of a known gene (ZTB18). (B) Principal Component Analysis (PCA) of the methylation profile (promoters) of idiopathic (n = 11) and heritable (n = 10) PAH patients. The Pearson correlation coefficient (r) was calculated comparing the CpG means across idiopathic and heritable groups.