Table 3. Enrichment analysis based on the wiki pathway and OMIM disease libraries for differentially methylated promoters in PAH patients.
| Term in each category | P-value | Z-score | Genes |
|---|---|---|---|
| Wiki pathway | |||
| Hs_Myometrial_Relaxation_and_Contraction_Pathways_WP289_21289 | 0.002 | −1.848 | IGFBP1;GPR182;ADCY4;GNG8;OXT;ACTB;ETS2 |
| Hs_Statin_Pathway_PharmGKB_WP430_29996 | 0.025 | −1.430 | ABCA1;APOA4 |
| Hs_Statin_Pathway_PharmGKB_WP430_21586 | 0.025 | −1.219 | ABCA1;APOA4 |
| Hs_Nuclear_receptors_in_lipid_metabolism_and_toxicity_WP299_21309 | 0.044 | −1.191 | ABCA1;ABCB4 |
| Hs_Inflammatory_Response_Pathway_WP453_21632 | 0.050 | −1.081 | COL1A1;ZAP70 |
| Hs_Adipogenesis_WP236_28133 | 0.054 | −1.517 | STAT5A;ADIPOQ;ID3;GATA2 |
| Hs_T_Cell_Receptor_Signaling_Pathway_WP69_20823 | 0.063 | −1.540 | STAT5A;ZAP70;NFAM1;ARHGDIB |
| Hs_Striated_Muscle_Contraction_WP383_21484 | 0.073 | −0.866 | DES;TCAP |
| Hs_IL-7_Signaling_Pathway_WP205_21111 | 0.088 | −1.116 | STAT5A;BCL2L11 |
| Hs_IL-3_Signaling_Pathway_WP286_21281 | 0.108 | −1.278 | STAT5A;BCL2L11;GATA2 |
| OMIM Disease | |||
| cardiomyopathy,_dilated | 0.000 | −1.973 | DES;TCAP;LDB3;MYH7 |
| cardiomyopathy | 0.001 | −1.861 | DES;TCAP;LDB3;MYH7 |
| myopathy | 0.011 | −1.456 | DES;LDB3;MYH7 |
| fibrosis | 0.124 | 0.313 | TERT |
Only enriched terms with P-value less than 5% are represented.