Table 4. List of the 48 differentially methylated promoter genes identified by Ingenuity pathway analysis (IPA) to be involved in metabolic processes.
| FC | Symbol | Gene Name | Location | Type(s) |
|---|---|---|---|---|
| 2,000 | ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | Plasma Membrane | transporter |
| 2,000 | ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | Plasma Membrane | transporter |
| 2,000 | ACTB | actin, beta | Cytoplasm | other |
| −2,000 | ADAM12 | ADAM metallopeptidase domain 12 | Plasma Membrane | peptidase |
| 2,000 | ADIPOQ | adiponectin, C1Q and collagen domain containing | Extracellular Space | other |
| 2,000 | APCS | amyloid P component, serum | Extracellular Space | other |
| 2,000 | APOA4 | apolipoprotein A-IV | Extracellular Space | transporter |
| 2,000 | APOBEC1 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 | Cytoplasm | enzyme |
| 2,000 | ASIC5 | acid sensing (proton gated) ion channel family member 5 | Plasma Membrane | ion channel |
| −2,000 | BCL2L11 | BCL2-like 11 (apoptosis facilitator) | Cytoplasm | other |
| 2,000 | CD300C | CD300c molecule | Plasma Membrane | transmembrane receptor |
| 2,000 | CDH17 | cadherin 17, LI cadherin (liver-intestine) | Plasma Membrane | transporter |
| 2,000 | CLEC4M | C-type lectin domain family 4, member M | Plasma Membrane | other |
| 2,000 | COL1A1 | collagen, type I, alpha 1 | Extracellular Space | other |
| 2,000 | CRP | C-reactive protein, pentraxin-related | Extracellular Space | other |
| 2,000 | CX3CR1 | chemokine (C-X3-C motif) receptor 1 | Plasma Membrane | G-protein coupled receptor |
| 2,000 | DKK3 | dickkopf WNT signaling pathway inhibitor 3 | Extracellular Space | cytokine |
| −2,000 | ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | Nucleus | transcription regulator |
| 2,000 | FAIM3 | Fas apoptotic inhibitory molecule 3 | Plasma Membrane | other |
| 2,000 | FERMT1 | fermitin family member 1 | Plasma Membrane | other |
| 2,000 | FGF1 | fibroblast growth factor 1 (acidic) | Extracellular Space | growth factor |
| 2,000 | GABRA5 | gamma-aminobutyric acid (GABA) A receptor, alpha 5 | Plasma Membrane | ion channel |
| 2,000 | HBG2 | hemoglobin, gamma G | Cytoplasm | other |
| 2,000 | IGFBP1 | insulin-like growth factor binding protein 1 | Extracellular Space | other |
| −2,000 | KLC1 | kinesin light chain 1 | Cytoplasm | other |
| −2,000 | let-7 | microRNA let-7a-1 | Cytoplasm | microRNA |
| 2,000 | LPPR4 | lipid phosphate phosphatase-related protein type 4 | Plasma Membrane | phosphatase |
| 2,000 | LTC4S | leukotriene C4 synthase | Cytoplasm | enzyme |
| 2,000 | MAT1A | methionine adenosyltransferase I, alpha | Cytoplasm | enzyme |
| 2,000 | MGMT | O-6-methylguanine-DNA methyltransferase | Nucleus | enzyme |
| −2,000 | mir-10 | microRNA 100 | Other | microRNA |
| 2,000 | mir-133 | microRNA 133b | Cytoplasm | microRNA |
| −2,000 | mir-26 | microRNA 26b | Cytoplasm | microRNA |
| 2,000 | MT2A | metallothionein 2A | Cytoplasm | other |
| 2,000 | NEBL | nebulette | Plasma Membrane | other |
| 2,000 | NKX2-5 | NK2 homeobox 5 | Nucleus | transcription regulator |
| 2,000 | NR1I2 | nuclear receptor subfamily 1, group I, member 2 | Nucleus | ligand-dependent nuclear receptor |
| 2,000 | PRLR | prolactin receptor | Plasma Membrane | transmembrane receptor |
| 2,000 | RNLS | renalase, FAD-dependent amine oxidase | Extracellular Space | enzyme |
| −2,000 | S100A10 | S100 calcium binding protein A10 | Cytoplasm | other |
| 2,000 | S100A9 | S100 calcium binding protein A9 | Cytoplasm | other |
| 2,000 | SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | Plasma Membrane | transporter |
| 2,000 | STAB2 | stabilin 2 | Plasma Membrane | transmembrane receptor |
| −2,000 | TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | Extracellular Space | cytokine |
| 2,000 | TYROBP | TYRO protein tyrosine kinase binding protein | Plasma Membrane | transmembrane receptor |
| 2,000 | ADAM28 | ADAM Metallopeptidase Domain 28 | Extracellular Space | enzyme |
| −2,000 | STAT5A | Signal Transducer And Activator Of Transcription 5A | Nucleus | transcription factor |
| −2,000 | MIR1207 | MicroRNA 1207 | Cytoplasm | microRNA |
FC = Fold change (2.000 for hyper-methylated genes and −2.000 for hypomethylated genes).