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. 2017 Jun 21;8(32):53154–53167. doi: 10.18632/oncotarget.18587

Figure 1. BHLH platform design and drug screen.

Figure 1

(A) The reporter vector consists of 12 bHLH binding elements (E-boxes), as 4 copies of 3 unique sequences, driving luciferase. (B) A screen of repurposed libraries yielded 271 hits above 3 standard deviations from the mean and 30 above 6 standard deviations from the mean (red line). (C) A histogram illustrates that the normal distribution peak from the compounds (blue) coincides with the DMSO peak (green). (D) Seventy unique hits were confirmed in triplicate and plotted in descending Z’, revealing enrichment for the statin class of compounds.