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. 2017 Jun 21;8(32):53154–53167. doi: 10.18632/oncotarget.18587

Figure 6. Pitavastatin represses Rb phosphorylation and E2F target gene expression.

Figure 6

PANC1, BxPC3, and 779e cells +/−10 μM pitavastatin treatment were harvested for protein and RNA expression. (A) Western blot analysis of Rb phosphorylation status at Ser807/811 and Ser608, total Rb, and GAPDH control. RT-qPCR of (B) CDC6, (C) DHFR, (D) ORC1, and (E) CENPA. Data are represented as mean +/−SD, *p≤0.05, **p≤0.01, ***p≤0.001, ****p≤0.0001.