Table 2. Basic information of candidate SNPs in Han subjects.
| SNP_ID | Gene | Alleles A/B | Case (N) | HWE Case | Control (N) | HWE Control | OR (95% CI) | p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AB | BB | AA | AB | BB | |||||||
| rs2230597 | EPHA2 | G/A | 4 | 21 | 45 | 0.470 | 3 | 5 | 22 | 0.106 | 1.422(0.627-3.229) | 0.398 |
| rs6678616 | C/T | 0 | 4 | 66 | 1.000 | 1 | 5 | 24 | 1.000 | 0.312(0.081-1.206) | 0.076 | |
| rs2291804 | C/T | 0 | 3 | 67 | 1.000 | 1 | 8 | 21 | 1.000 | 0.137(0.035-0.536) | 0.001 | |
| rs35127370 | C/T | 0 | 13 | 57 | 1.000 | 1 | 7 | 22 | 1.000 | 0.746(0.281-1.976) | 0.554 | |
| rs2291805 | C/T | 0 | 13 | 57 | 1.000 | 2 | 13 | 15 | 0.636 | 0.293(0.129-0.665) | 0.002 | |
| rs3768294 | G/A | 0 | 14 | 56 | 1.000 | 2 | 14 | 14 | 0.390 | 0.291(0.131-0.647) | 0.002 | |
| rs6678618 | C/T | 0 | 4 | 66 | 1.000 | 1 | 5 | 24 | 1.000 | 0.311(0.080-1.260) | 0.076 | |
| rs6603883 | G/A | 1 | 17 | 52 | 1.000 | 1 | 8 | 21 | 1.000 | 0.981(0.403-2.388) | 0.967 | |
| rs3754334 | G/A | 0 | 20 | 50 | 0.337 | 2 | 15 | 13 | 0.370 | 0.402(0.192-0.840) | 0.014 | |
| rs6603856 | G/A | 0 | 13 | 57 | 1.000 | 2 | 12 | 16 | 1.000 | 0.321(0.140-0.737) | 0.006 | |
| rs6669624 | G/A | 0 | 12 | 58 | 1.000 | 2 | 10 | 18 | 1.000 | 0.359(0.150-0.856) | 0.017 | |
| rs11260742 | T/C | 1 | 13 | 56 | 0.568 | 3 | 11 | 16 | 1.000 | 0.344(0.155-0.761) | 0.007 | |
| rs13375644 | C/T | 3 | 14 | 53 | 1.000 | 4 | 11 | 15 | 1.000 | 0.296(0.123-0.713) | 0.005 | |
| rs10907223 | G/A | 0 | 13 | 57 | 1.000 | 2 | 11 | 17 | 1.000 | 0.354(0.152-0.821) | 0.013 | |
| rs699 | AGT | G/A | 1 | 23 | 46 | 0.680 | 2 | 17 | 11 | 0.198 | 0.446(0.222-0.897) | 0.022 |
| rs11122576 | T/C | 7 | 35 | 28 | 0.600 | 3 | 10 | 17 | 0.644 | 1.692(0.845-3.389) | 0.135 | |
| rs5046 | G/A | 3 | 25 | 42 | 1.000 | 1 | 8 | 21 | 1.000 | 1.778(0.763-4.143) | 0.179 | |
| rs3789679 | G/A | 7 | 37 | 26 | 0.594 | 3 | 10 | 17 | 0.604 | 1.846(0.904-3.769) | 0.090 | |
| rs1926722 | C/A | 11 | 31 | 28 | 0.617 | 3 | 12 | 15 | 0.662 | 1.469(0.759-2.844) | 0.252 | |
| rs4762 | G/A | 1 | 5 | 64 | 0.146 | 2 | 8 | 20 | 1.000 | 0.253(0.091-0.701) | 0.005 | |
| rs28730748 | G/A | 3 | 6 | 61 | 0.196 | 1 | 7 | 22 | 1.000 | 0.455(0.157-1.321) | 0.140 | |
| rs2071406 | A/G | 1 | 19 | 50 | 1.000 | 2 | 8 | 20 | 1.000 | 0.847(0.372-1.931) | 0.693 | |
| rs5050 | T/G | 1 | 13 | 56 | 0.568 | 2 | 8 | 20 | 1.000 | 0.576(0.242-1.37) | 0.208 | |
| rs11122575 | A/G | 8 | 15 | 47 | 0.000 | 2 | 10 | 18 | 1.000 | 1.277(0.554-2.942) | 0.565 | |
| rs3827749 | G/A | 3 | 28 | 39 | 0.744 | 3 | 14 | 13 | 1.000 | 0.609(0.313-1.185) | 0.143 | |
| rs5051 | T/C | 1 | 23 | 46 | 0.680 | 2 | 16 | 12 | 0.413 | 0.413(0.207-0.826) | 0.011 | |
| rs11568020 | C/T | 0 | 7 | 63 | 1.000 | 0 | 2 | 28 | 1.000 | 3.000(0.361-24.95) | 0.287 | |
| rs2478523 | A/G | 8 | 28 | 19 | 0.782 | 5 | 13 | 12 | 1.000 | 0.841(0.431-1.638) | 0.610 | |
SNP: Single-nucleotide polymorphism; OR: odds ratio; 95% CI: 95% confidence interval; HWE: Hardy-Weinberg equilibrium;
Site with HWE p≤0.05 excluded; p<0.05 indicates statistical significance for allele model.