Table 3. Basic information of candidate SNPs in Tibetan subjects.
| SNP_ID | Gene | Alleles A/B | Case (N) | HWE Case | Control (N) | HWE Control | OR (95% CI) | p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AB | BB | AA | AB | BB | |||||||
| rs2230597 | EPHA2 | G/A | 0 | 22 | 48 | 0.195 | 0 | 9 | 21 | 1.000 | 1.056(0.455-2.453) | 0.898 |
| rs6678616 | C/T | 0 | 3 | 67 | 1.000 | 0 | 2 | 28 | 1.000 | 0.635(0.103-3.901) | 0.621 | |
| rs2291804 | C/T | 0 | 2 | 68 | 1.000 | 0 | 0 | 30 | 1.000 | 0.264(0.198-3.578) | 0.352 | |
| rs35127370 | C/T | 0 | 14 | 56 | 1.000 | 0 | 6 | 24 | 1.000 | 1.000(0.365-2.74) | 1.000 | |
| rs2291805 | C/T | 1 | 10 | 59 | 0.402 | 1 | 4 | 25 | 0.241 | 0.844(0.301-2.364) | 0.746 | |
| rs3768294 | G/A | 3 | 13 | 54 | 0.480 | 3 | 4 | 23 | 0.257 | 0.910(0.328-2.53) | 0.857 | |
| rs6678618 | C/T | 0 | 3 | 67 | 1.000 | 0 | 2 | 28 | 1.000 | 0.635(0.103-3.901) | 0.621 | |
| rs6603883 | G/A | 0 | 18 | 52 | 0.588 | 0 | 8 | 22 | 1.000 | 0.959(0.392-2.344) | 0.927 | |
| rs3754334 | G/A | 1 | 17 | 52 | 1.000 | 1 | 7 | 22 | 0.505 | 0.890(0.377-2.098) | 0.790 | |
| rs6603856 | G/A | 2 | 12 | 56 | 0.519 | 1 | 5 | 24 | 0.325 | 0.855(0.327-2.238) | 0.749 | |
| rs6669624 | G/A | 4 | 12 | 54 | 1.000 | 1 | 3 | 26 | 0.165 | 1.100(0.370-3.275) | 0.864 | |
| rs11260742 | T/C | 2 | 11 | 57 | 0.162 | 1 | 5 | 24 | 0.325 | 0.910(0.350-2.356) | 0.844 | |
| rs13375644 | C/T | 3 | 18 | 49 | 0.048 | 3 | 5 | 22 | 0.121 | 1.150(0.343-3.86) | 0.821 | |
| rs10907223 | G/A | 1 | 12 | 57 | 0.514 | 1 | 5 | 24 | 0.325 | 0.841(0.321-2.202) | 0.725 | |
| rs699 | AGT | G/A | 7 | 28 | 35 | 0.776 | 2 | 16 | 12 | 0.423 | 0.857(0.449-1.637) | 0.640 |
| rs11122576 | T/C | 5 | 33 | 32 | 0.573 | 2 | 14 | 14 | 0.688 | 1.034(0.535-1.999) | 0.920 | |
| rs5046 | G/A | 0 | 13 | 57 | 1.000 | 0 | 7 | 23 | 1.000 | 0.775(0.293-2.051) | 0.607 | |
| rs3789679 | G/A | 4 | 28 | 38 | 1.000 | 3 | 10 | 17 | 0.644 | 1.027(0.501-2.106) | 0.942 | |
| rs1926722 | C/A | 5 | 30 | 35 | 0.777 | 2 | 14 | 14 | 0.688 | 0.933(0.481-1.811) | 0.838 | |
| rs4762 | G/A | 0 | 6 | 64 | 1.000 | 0 | 3 | 27 | 1.000 | 0.851(0.206-3.52) | 0.823 | |
| rs28730748 | G/A | 2 | 12 | 56 | 0.519 | 2 | 10 | 18 | 0.553 | 0.519(0.216-1.251) | 0.139 | |
| rs2071406 | A/G | 2 | 26 | 42 | 0.720 | 1 | 9 | 20 | 1.000 | 1.215(0.563-2.62) | 0.619 | |
| rs5050 | T/G | 1 | 7 | 62 | 0.240 | 0 | 6 | 24 | 1.000 | 0.618(0.210-1.822) | 0.380 | |
| rs11122575 | A/G | 4 | 16 | 40 | 0.397 | 4 | 6 | 20 | 1.000 | 1.528(0.576-4.051) | 0.392 | |
| rs3827749 | G/A | 1 | 31 | 38 | 0.093 | 2 | 10 | 18 | 0.632 | 1.013(0.496-2.07) | 0.971 | |
| rs5051 | T/C | 7 | 30 | 33 | 1.000 | 2 | 16 | 12 | 0.423 | 0.917(0.481-1.746) | 0.791 | |
| rs11568020 | C/T | 1 | 1 | 68 | 0.022 | 0 | 2 | 28 | 1.000 | 0.635(0.103-3.901) | 0.621 | |
| rs2478523 | A/G | 6 | 30 | 34 | 1.000 | 3 | 12 | 15 | 0.034 | 2.629(1.005-6.876) | 0.043 | |
SNP: Single-nucleotide polymorphism; OR: odds ratio; 95% CI: 95% confidence interval; HWE: Hardy-Weinberg equilibrium;
Site with HWE p≤0.05 excluded; p<0.05 indicates statistical significance for allele model.