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. 2017 Jun 7;8(32):53313–53325. doi: 10.18632/oncotarget.18397

Table 3. Differential Metabonomic Pathways for ALD versus HCV-Infected HCC Tumors by Impact Ranking.

Pre-sensitivity analysis P-value -Log(P) Holm P FDR Impact
Synthesis and degradation of ketone bodies 1.95E-15 33.87 4.29E-14 8.57E-15 0.70
Glycine, serine and threonine metabolism 5.33E-13 28.26 8.81E-12 1.68E-12 0.19
Alanine, aspartate and glutamate metabolism 2.47E-11 24.43 3.70E-10 4.93E-11 0.06
Phenylalanine metabolism 5.18E-13 28.29 8.81E-12 1.68E-12 0.05
Butanoate metabolism 1.95E-15 33.87 4.29E-14 8.57E-15 0.04
Taurine and hypotaurine metabolism 2.47E-11 24.43 3.70E-10 4.93E-11 0.03
Arginine and proline metabolism 3.92E-11 23.96 4.32E-10 7.19E-11 0.03
Propanoate metabolism 1.95E-15 33.87 4.29E-14 8.57E-15 0.03
Primary bile acid biosynthesis 1.84E-08 17.81 1.47E-07 1.93E-08 0.01
Purine metabolism 2.34E-10 22.18 2.34E-09 3.96E-10 0.01
Valine, leucine and isoleucine degradation 1.95E-15 33.87 4.29E-14 8.57E-15 0.00
Tyrosine metabolism 1.95E-15 33.87 4.29E-14 8.57E-15 0.00
Cysteine and methionine metabolism 2.47E-11 24.43 3.70E-10 4.93E-11 0.00
Selenoamino acid metabolism 2.47E-11 24.43 3.70E-10 4.93E-11 0.00
Aminoacyl-tRNA biosynthesis 1.19E-09 20.55 1.07E-08 1.87E-09 0.00
Lysine degradation 1.84E-08 17.81 1.47E-07 1.93E-08 0.00
Cyanoamino acid metabolism 1.84E-08 17.81 1.47E-07 1.93E-08 0.00
Glutathione metabolism 1.84E-08 17.81 1.47E-07 1.93E-08 0.00
Thiamine metabolism 1.84E-08 17.81 1.47E-07 1.93E-08 0.00
Porphyrin and chlorophyll metabolism 1.84E-08 17.81 1.47E-07 1.93E-08 0.00
Nitrogen metabolism 1.84E-08 17.81 1.47E-07 1.93E-08 0.00
Methane metabolism 6.78E-04 7.30 6.78E-04 6.78E-04 0.00
Post-sensitivity analysis P-value -Log(P) Holm P FDR Impact
Synthesis and degradation of ketone bodies 1.95E-15 33.87 2.73E-14 5.46E-15 0.70
Alanine, aspartate and glutamate metabolism 2.47E-11 24.43 1.97E-10 3.14E-11 0.06
Phenylalanine metabolism 5.18E-13 28.29 4.66E-12 1.21E-12 0.05
Butanoate metabolism 1.95E-15 33.87 2.73E-14 5.46E-15 0.04
Taurine and hypotaurine metabolism 2.47E-11 24.43 1.97E-10 3.14E-11 0.03
Arginine and proline metabolism 3.92E-11 23.96 1.97E-10 4.23E-11 0.03
Propanoate metabolism 1.95E-15 33.87 2.73E-14 5.46E-15 0.03
Glycine, serine and threonine metabolism 3.92E-11 23.96 1.97E-10 4.23E-11 0.00
Valine, leucine and isoleucine degradation 1.95E-15 33.87 2.73E-14 5.46E-15 0.00
Tyrosine metabolism 1.95E-15 33.87 2.73E-14 5.46E-15 0.00
Cysteine and methionine metabolism 2.47E-11 24.43 1.97E-10 3.14E-11 0.00
Selenoamino acid metabolism 2.47E-11 24.43 1.97E-10 3.14E-11 0.00
Aminoacyl-tRNA biosynthesis 2.47E-11 24.43 1.97E-10 3.14E-11 0.00
Methane metabolism 9.15E-04 7.00 9.15E-04 9.15E-04 0.00