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. 2017 Jun 16;8(32):53387–53404. doi: 10.18632/oncotarget.18508

Figure 7. Knocking down Aurora A or B expression in KYSE450 esophageal cancer cells dramatically inhibits tumor growth in a xenograft mouse model.

Figure 7

Mice injected with knockdown cells exhibited decreased tumor volume (A) and weight (B) compared with mice injected with mock. The asterisks (*, **) indicate a significant (p < 0.05, p < 0.01, respectively) decrease in tumor volume. (C) Immunohistochemistry analysis was used to determine the level of Ki-67, phosphorylation of histone H3 (Ser10) and Bax. The integrated optical density (IOD) was evaluated using the Image-Pro Plus (v.6.2). The asterisks (*, **) indicate a significant (p < 0.05, p < 0.01, respectively) decrease in the shRNA transfection groups compared with mock control.