Table 1. Kinase docking results indicate that Aurora A and B are potential targets of APIO-EE-9.

Kinase	Docking	Kinase	Docking	Kinase	Docking
	Score		Score		Score
Aurora B	-9.212	RSK1	−7.73	PIM1	−6.813
PDK1	−9.058	EGFR	−7.684	AKT2	−6.772
ERK1	−8.797	MEK2	−7.682	EGFR (L858R)	−6.675
MLK1	−8.793	c-MET	−7.457	RSK2 (CTD)	−6.596
Aurora A	-8.597	CHK2	−7.433	RSK2 (NTD)	−6.15
PI3 Kinase (p110/p85)	−8.424	ALK	−7.154	GSK3β	−5.753
EGFR (T790M)	−8.404	JNK1	−7.15	AKT1	−5.102
MSK1	−8.19	P38	−7.095	ERK2	−5.01
ASK1	−7.911	MEK1	−6.909	CHK1	−4.371