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. 2017 Jun 21;8(32):53518–53530. doi: 10.18632/oncotarget.18591

Figure 7. SHP2 depletion increase the antigenicity of PCa cells.

Figure 7

T-cell activation was measured as the CD25 MFI of CD8 T cells in healthy donor PBMC cocultured with PCa after pretreatment with SHP2 siRNA or control siRNA. (A) Representative flow histograms of CD25 of CD8 T cells are shown. Full black line depicts isotype group. Full gray line depicts control siRNA group. Black line depicts SHP2 siRNA group. Dashed line depicts PBMC only group. (B) Bar graphs represent mean ±SD from duplicate samples in three independent experiments.