Table 3. Pooled analysis for the association between TNF-α rs1800629 polymorphism and the risk of SCC.
| Comparison | Subgroup | Test of association | Number | |||||
|---|---|---|---|---|---|---|---|---|
| ORs | 95% CIs | z | Passociation | Studies | Case | Control | ||
| A vs G | overall | 1.18 | 0.92∼1.51 | 1.30 | 0.192 | 15 | 2739 | 5083 |
| Asian | 1.18 | 0.73∼1.92 | 0.67 | 0.501 | 9 | 1573 | 1603 | |
| Caucasian | 1.07 | 0.93∼1.22 | 0.94 | 0.349 | 6 | 1166 | 3480 | |
| ESCC | 1.19 | 0.99∼1.44 | 1.84 | 0.066 | 4 | 869 | 1964 | |
| LSCC | 1.39 | 0.72∼2.36 | 0.87 | 0.385 | 5 | 376 | 1581 | |
| OSCC | 1.19 | 0.49∼2.88 | 0.39 | 0.697 | 4 | 608 | 524 | |
| AA vs GG | overall | 1.62 | 1.15∼2.29 | 2.73 | 0.006 | 14 | 2674 | 5018 |
| Asian | 3.67 | 1.89∼7.16 | 3.82 | <0.001 | 8 | 1508 | 1538 | |
| Caucasian | 1.08 | 0.70∼1.66 | 0.33 | 0.743 | 6 | 1166 | 3480 | |
| ESCC | 1.24 | 0.66∼2.32 | 0.68 | 0.497 | 4 | 869 | 1964 | |
| LSCC | 2.72 | 1.32∼5.61 | 2.72 | 0.007 | 4 | 311 | 1516 | |
| OSCC | 3.91 | 1.38∼11.05 | 2.57 | 0.010 | 4 | 608 | 524 | |
| GA vs GG | overall | 1.10 | 0.87∼1.39 | 0.77 | 0.439 | 15 | 2739 | 5083 |
| Asian | 1.05 | 0.67∼1.64 | 0.20 | 0.839 | 9 | 1573 | 1603 | |
| Caucasian | 1.08 | 0.92∼1.27 | 0.97 | 0.334 | 6 | 1166 | 3480 | |
| ESCC | 1.23 | 0.95∼1.61 | 1.55 | 0.120 | 4 | 869 | 1964 | |
| LSCC | 1.27 | 0.74∼2.18 | 0.85 | 0.393 | 5 | 376 | 1581 | |
| OSCC | 0.99 | 0.51∼1.95 | 0.02 | 0.986 | 4 | 608 | 524 | |
| GA+AA vs GG | overall | 1.15 | 0.90∼1.47 | 1.14 | 0.255 | 16 | 2836 | 5235 |
| Asian | 1.14 | 0.73∼1.77 | 0.56 | 0.577 | 10 | 1670 | 1755 | |
| Caucasian | 1.08 | 0.93∼1.26 | 0.99 | 0.324 | 6 | 1166 | 3480 | |
| ESCC | 1.24 | 0.97∼1.57 | 1.73 | 0.084 | 4 | 869 | 1964 | |
| LSCC | 1.31 | 0.71∼2.40 | 0.86 | 0.389 | 5 | 376 | 1581 | |
| OSCC | 1.12 | 0.58∼2.15 | 0.33 | 0.738 | 5 | 705 | 676 | |
| AA vs GG+GA | overall | 1.56 | 1.10∼2.20 | 2.53 | 0.012 | 14 | 2674 | 5018 |
| Asian | 3.52 | 1.80∼6.88 | 3.68 | <0.001 | 8 | 1508 | 1538 | |
| Caucasian | 1.05 | 0.68∼1.62 | 0.22 | 0.829 | 6 | 1166 | 3480 | |
| ESCC | 1.19 | 0.64∼2.22 | 0.56 | 0.577 | 4 | 869 | 1964 | |
| LSCC | 2.48 | 1.20∼5.12 | 2.45 | 0.014 | 4 | 311 | 1516 | |
| OSCC | 3.84 | 1.34∼11.01 | 2.50 | 0.012 | 4 | 608 | 524 | |
| carrier A vs G | overall | 1.12 | 0.91∼1.39 | 1.06 | 0.287 | 15 | 2739 | 5083 |
| Asian | 1.12 | 0.74∼1.69 | 0.52 | 0.604 | 9 | 1573 | 1603 | |
| Caucasian | 1.06 | 0.91∼1.22 | 0.73 | 0.468 | 6 | 1166 | 3480 | |
| ESCC | 1.17 | 0.96∼1.42 | 1.59 | 0.111 | 4 | 869 | 1964 | |
| LSCC | 1.24 | 0.75∼2.07 | 0.84 | 0.402 | 5 | 376 | 1581 | |
| OSCC | 1.10 | 0.54∼2.24 | 0.27 | 0.789 | 4 | 608 | 524 | |
ESCC: esophageal squamous cell carcinoma; LSCC: lung squamous cell carcinoma; OSCC: oral squamous cell carcinoma; Ors: odd ratios; CIs: confidence intervals.