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. 2017 Sep 1;12(9):e0184117. doi: 10.1371/journal.pone.0184117

Fig 7. Effects of 2-pyridones on level of soluble aS in fly brain extracts of 20 days old flies.

Fig 7

Mean soluble aS levels were measured with antibody specific to human aS in ELISA test. Controls: vehicle-treated nsyb-Gal4 outcrossed with Oregon R flies (CTRL VEH) or aS expressing flies (AS VEH, white bars). Tested compounds were FN075 (AS FN075, magenta bars) or MS400 (AS MS400, green bars) or C10 (AS C10, blue bars) at 100μM concentration. Bars represent mean values (n = 2). Error bars indicate ± SD. * P < 0.05; ** P < 0.01; *** P <0.001. Multivariate GLM followed by Fisher's post hoc showed P = 0.084 for AS FN075 vs AS VEH, P<0.001 for AS MS400 vs AS VEH and P = 0.002 for AS C10 vs AS VEH. For raw data see S7 Table.