Fig 3. Patterns of serum reactivity to MTB proteins with their odds ratios that differed significantly in at least one of the 4 groups.

The heatmap shows the odds ratio of the serum reactivity from 4 groups to each of the 47 proteins. Each column represents one protein, odds ratios (rows) are visualized as a color spectrum. The heatmap was generated using the ComplexHeatmap package in R. The clustering was performed using the pvclust package with multiscale bootstrap resampling. Arguments passed to the pvclust command for the hierarchical clustering method (method.hclust) was “median” and for the distance method (method.dist) was “maximum”. The confidence intervals were overlaid on the heatmap using the ggplot2 package.