Table 7. Associations between nuclear, cytoplasmic, and nuclear/cytoplasmic ratio of BRCA1 expression (IHC staining) and clinicopathologic features in breast cancer.
| Variable | Nuclear | Cytoplasmic | ||||
|---|---|---|---|---|---|---|
| Low (%) | High (%) | P-value | Low (%) | High (%) | P-value | |
| Age | 0.09 | 0.048 | ||||
| Young <50y | 44.1 | 55.9 | 47.1 | 52.9 | ||
| Old > = 50y | 54.8 | 45.2 | 60.3 | 39.7 | ||
| Race | ||||||
| White non-Hispanic | 50 | 50 | 56.4 | 43.6 | ||
| Black | 50 | 50 | 57.5 | 42.5 | ||
| Hispanic | 53.8 | 46.2 | 54.5 | 45.5 | ||
| Tumor stage | ||||||
| Stage 0 | 100 | 0 | 100 | 0 | ||
| Stage 1 | 52.6 | 47.4 | 56.7 | 43.3 | ||
| Stage 2 | 49.5 | 50.5 | 57.3 | 42.7 | ||
| Stage 3 | 55.6 | 44.4 | 54.3 | 45.7 | ||
| Stage 4 | 50 | 50 | 50 | 50 | ||
| Tumor grade | 0.035 | 0.09 | ||||
| Grade 1 | 35.6 | 64.4 | 42.2 | 57.8 | ||
| Grade 2 | 58.4 | 41.6 | 60.4 | 39.6 | ||
| Grade 3 | 53.6 | 46.4 | 59.4 | 40.6 | ||
| ER | 0.11 | |||||
| 0 (H-score<10) | 73.3 | 26.7 | 73.3 | 26.7 | ||
| 1 (H-score = 11–100) | 52 | 48 | 54.7 | 45.3 | ||
| 2 (H-score = 101–200) | 56.8 | 43.2 | 61.4 | 38.6 | ||
| 3 (H-score = 201–300) | 44.1 | 55.9 | 51.7 | 48.3 | ||
| PR | 0.19 | |||||
| 0 (H-score<10) | 57.5 | 42.5 | 62.2 | 37.8 | ||
| 1 (H-score = 11–100) | 51.9 | 48.1 | 55.6 | 44.6 | ||
| 2 (H-score = 101–200) | 51.4 | 48.6 | 59.4 | 40.6 | ||
| 3 (H-score = 201–300) | 41.7 | 58.3 | 48.8 | 51.2 | ||
| Her2 | ||||||
| Negative (ASCO/CAP score<3) | 52.1 | 47.9 | 57.1 | 42.9 | ||
| Positive (ASCO/CAP score = 3) | 45.7 | 54.3 | 51.4 | 48.6 | ||
| CK5/6 | 0.013 | |||||
| Negative (< 5% cells stain) | 55.8 | 44.2 | 61.5 | 38.5 | ||
| Positive (≥5% cells stain) | 43.2 | 56.8 | 46.3 | 53.7 | ||
| EGFR | 0.12 | 0.044 | ||||
| Negative (ASCO/CAP score<3) | 52.6 | 47.4 | 58.3 | 41.7 | ||
| Positive (ASCO/CAP score = 3) | 39.3 | 60.7 | 39.3 | 60.7 | ||
| Ki67 | 0.10 | 0.017 | ||||
| Low (<14% cells stain) | 57.3 | 42.7 | 61.5 | 38.5 | ||
| High (≥14% cells stain) | 41.7 | 58.3 | 47.2 | 52.8 | ||
| P53 | ||||||
| Low (<20% cells stain) | 52.6 | 47.4 | 57.3 | 42.7 | ||
| High (≥20% cells stain) | 47.5 | 52.5 | 52.5 | 47.5 | ||
| bcl2 | 0.014 | 0.017 | ||||
| Negative (<20% cells stain) | 59.3 | 40.7 | 63.7 | 36.3 | ||
| Positive (≥20% cells stain) | 44.7 | 55.3 | 49.6 | 50.4 | ||
| Nuclear AR | 0.008 | 0.03 | ||||
| Low (H-score<mean) | 58 | 42 | 61.5 | 38.5 | ||
| High (H-score≥mean) | 41.4 | 58.6 | 48.5 | 51.5 | ||
| Histological subtypes | ||||||
| Ductal | 49.7 | 50.3 | 53.8 | 46.2 | ||
| Lobular | 58.6 | 41.4 | 69 | 31 | ||
| Mixed ductal and lobular | 64.7 | 35.3 | 64.7 | 35.3 | ||
| Others | 38.5 | 61.5 | 46.2 | 53.8 | ||
| Molecular subtypes | ||||||
| LuminalA | 50.6 | 49.4 | 57 | 43 | ||
| LuminalB | 28.6 | 71.4 | 35.7 | 64.3 | ||
| Triple Negative | 57.1 | 42.9 | 55.6 | 44.4 | ||
| Her2 | 55.6 | 44.4 | 61.9 | 38.1 | ||
| Basal-like | 0.015 | 0.003 | ||||
| No | 57 | 43 | 63.8 | 36.2 | ||
| Yes | 42.6 | 57.4 | 45.4 | 54.6 | ||
| Early family history | ||||||
| No | 51.7 | 48.3 | 56.2 | 43.8 | ||
| Yes | 50 | 50 | 58.3 | 41.7 | ||