Table 1.
Demographic and Clinical characteristics of Patients Characterized by Genetic Condition or No Genetic Condition
| Variable | No known Genetic Condition N=80540 |
Trisomy 21 N=9473 |
Trisomy 13/18 N=156 |
22 q11 N=715 |
Other Genetic Conditions N=4369 |
|---|---|---|---|---|---|
| Age in monthsa (Median, IQR) Age Groups (n, %) |
7 (1, 47) | 5 (3, 10) | 3.5 (0, 8) | 3 (0, 28) | 6 (0, 41) |
| 0–1 months | 22540 (28) | 1011 (11) | 58 (37) | 319 (45) | 1355 (31) |
| 2–12 months | 23179 (29) | 6437 (68) | 65 (42) | 172 (20) | 1283 (30) |
| 13–60 months | 18488 (23) | 1243 (13) | 20 (13) | 90 (13) | 884 (20) |
| 5–10 years | 7192 (9) | 419 (4) | 9 (6) | 87 (8) | 383 (9) |
| >10 years | 8485 (11) | 335 (4) | 4 (3) | 74 (11) | 434 (10) |
| Missing Age | 656 (1) | 28 (<1) | 0 | 3 (<1) | 31 (1) |
|
| |||||
| Male (%)a | 45816 (57) | 4385 (46) | 51 (33) | 366 (51) | 2140 (49) |
| Race (n, %)b | |||||
| White | 42391 (53) | 4977 (53) | 81 (52) | 373 (52) | 2373 (54) |
| Black | 9842 (12) | 1139 (12) | 24 (15) | 86 (12) | 460 (11) |
| Latino | 13749 (17) | 1774 (19) | 23 (15) | 133 (19) | 850 (20) |
| Asian | 2556 (3) | 205 (2) | 3 (2) | 27 (4) | 96 (2) |
| Other | 9252 (12) | 1076 (11) | 13 (8) | 75 (11) | 444 (10) |
| Missing Race | 2750 (3) | 302 (3) | 12 (8) | 21 (3) | 147 (3) |
|
| |||||
|
RACHS-1 Categories (n, %) a RACHS 1 |
8819 (11) | 398 (4) | 8 (5) | 11 (2) | 429 (10) |
| RACHS 2 | 27852 (35) | 3089 (33) | 74 (47) | 215 (30) | 1623 (37) |
| RACHS 3 | 30889 (38) | 5771 (61) | 61 (39) | 288 (40) | 1687 (39) |
| RACHS 4 | 9227 (12) | 187 (2) | 11 (7) | 188 (26) | 477 (11) |
| RACHS 5 | 133 (<1) | 8 (<1) | 0 | 5 (1) | 6 (<1) |
| RACHS 6 | 3620 (5) | 20 (<1) | 2 (1) | 8 (1) | 148 (3) |
|
| |||||
| ECMO (n, %) | 2353 (3) | 134 (1) | 5 (3) | 21 (3) | 167 (4)* |
| ECMO Mortality (n, %) Non ECMO Mortality (n, %) |
1092 (1) 1252 (2) |
66 (<1) 128 (1) |
5 (3) 15 (10)* |
16 (2)* 17 (2) |
87 (2) 187 (4) |
| In Hospital Death (n, %) | 2344 (3) | 194 (2)* | 20 (13)* | 33 (5)* | 274 (6) |
Continuous variables summarized by Median and Interquartile Range: 50th (25th–75th).
Categorical variables summarized by % (n).
a
Statistically significant difference between every group compared to no GC, p<.008
b
Statistically significant difference between T21 and 22q11, compared to no GC, p<.008
*
Statistically significant difference compared to no GC, p<.008.