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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Pharmacogenet Genomics. 2017 Oct;27(10):378–385. doi: 10.1097/FPC.0000000000000302

Table 1. Linear regression analysis of maximum decline in LVEF.

SNP ID, Chr, chromosome and Hg19 position. MAF, minor allele frequency, L95, lower and U95 upper 95% confidence intervals and P, p-value, is shown for Arms BC and Arm A additive linear regression analysis. Genotype count for each SNP is shown in the subset of patients with CHF, congestive heart failure, separated for Arms BC and Arm A, with genotype counts of allele 1 homozygote/heterozygote/allele 2 homozygote and minor allele frequency in parentheses.

ID Chr Position Hg19 Locus Arms BC- Max Drop in LVEF (N=800) Arm A- Max Drop in LVEF (N=391) CHF (n=17) genotype count and (MAF)
MAF Beta (L95−U95) P (2−tail) MAF Beta (L95−U95) P (2−tail) Arms BC Arm A
rs55756123 4 16,502,767 LDB2 0.02 −6.11 (−8.32 to −3.89) 8.93E-08 0.01 1.61 (−3.82 to 7.04) 0.56 0/3/7 (0.15) 0/0/7 (0.00)
rs10117876 9 121,859,107 BRINP1 0.01 −7.79 (−10.82 to −4.76) 5.86E-07 0.01 2.12 (−3.35 to 7.59) 0.44 0/1/9 (0.05) 0/0/7 (0.00)
rs7038023 9 121,859,198 BRINP1 0.01 −7.79 (−10.82 to −4.76) 5.86E-07 0.01 1.83 (−3.26 to 6.92) 0.48 0/1/9 (0.05) 0/0/7 (0.00)
rs7041012 9 121,859,463 BRINP1 0.01 −7.18 (−10.06 to −4.29) 1.34E-06 0.01 1.16 (−3.92 to 6.24) 0.66 0/1/9 (0.05) 0/0/7 (0.00)
rs1160584 9 121,861,009 BRINP1 0.01 −7.91 (−11.12 to −4.70) 1.62E-06 0.01 2.85 (−3.64 to 9.35) 0.38 0/1/9 (0.05) 0/0/7 (0.00)
rs230145 9 121,879,897 BRINP1 0.01 −7.91 (−11.12 to −4.70) 1.62E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs230144 9 121,882,710 BRINP1 0.01 −7.90 (−11.12 to −4.69) 1.70E-06 0.01 −1.76 (−7.70 to 4.19) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs230142 9 121,883,736 BRINP1 0.01 −7.91 (−11.12 to −4.70) 1.62E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs62573809 9 121,892,448 BRINP1 0.01 −6.88 (−9.84 to −3.93) 5.70E-06 0.01 −2.25 (−7.69 to 3.20) 0.42 0/1/9 (0.05) 0/0/7 (0.00)
rs16908078 9 121,893,380 BRINP1 0.01 −7.49 (−10.61 to −4.38) 2.95E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs7851490 9 121,894,217 BRINP1 0.01 −7.48 (−10.60 to −4.36) 3.12E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs7854066 9 121,899,889 BRINP1 0.01 −7.49 (−10.61 to −4.37) 3.04E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs62573837 9 121,900,834 BRINP1 0.01 −7.50 (−10.62 to −4.38) 2.88E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs76586195 9 121,902,640 BRINP1 0.01 −7.73 (−10.95 to −4.52) 2.90E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs7027658 9 121,904,365 BRINP1 0.01 −7.49 (−10.61 to −4.38) 2.95E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs75912020 9 121,909,304 BRINP1 0.01 −7.49 (−10.61 to −4.38) 2.95E-06 0.01 −1.77 (−7.71 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs76890184 9 121,910,252 BRINP1 0.01 −7.49 (−10.61 to −4.38) 2.95E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs58944852 9 121,912,974 BRINP1 0.01 −7.49 (−10.61 to −4.38) 2.87E-06 0.01 −1.76 (−7.70 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs62568637 9 121,917,144 BRINP1 0.01 −8.50 (−11.81 to −5.19) 6.01E-07 0.01 −1.77 (−7.72 to 4.18) 0.56 0/1/9 (0.05) 0/0/7 (0.00)
rs4305714 6 22,957,737 intergenic 0.24 −1.87 (−2.63 to −1.12) 1.39E-06 0.24 −0.51 (−1.64 to 0.63) 0.38 0/5/5 (0.25) 1/5/1 (0.50)
rs707557 20 56,942,312 RAB22A 0.40 1.46 (0.83 to 2.08) 5.62E-06 0.38 −0.31 (−1.33 to 0.71) 0.55 1/3/6 (0.25) 1/6/0 (0.57)
rs77679196 11 101,453,508 TRPC6 0.01 −7.00 (−10.05 to −3.96) 7.72E-06 0.01 −5.29 (−11.95 to 1.38) 0.12 0/2/8 (0.10) 0/0/7 (0.00)
rs7698718 4 189,555,947 LINC01060 0.22 1.78 (1.01 to 2.56) 7.73E-06 0.22 0.11 (−1.02 to 1.23) 0.86 1/2/7 (0.20) 0/5/2 (0.36)