Table 2. SNPs previously associated with ERBB2 cardiotoxicity (Arms BC).

Association analyses were performed assuming an additive effect in both linear and logistic regression models. For logistic regression, we report genotype counts, odds ratio (OR) and P-values (P) using the more stringent definition of cases as per Gomez Pena et al, 2015: Decrease of at least 10% points from baseline with a resulting LVEF of less than 50% or decrease of 15% with respect to baseline, or any decrease resulting in LVEF less than 45% at least once during the treatment or clinical manifestation of CHF.

		Linear Max drop in LVEF		Logistic LVEF literature
SNP ID	AA change	Beta, L95-U95	P	genotype case	genotype con	OR, L95-U95	P
rs1136201	I655V	−0.33 (−1.07 to 0.41)	0.39	GG=11	GG=39	0.941 (0.71 to 1.25)	0.67
				GA=59	GA=228
				AA=103	AA=360
rs1058808	P1170A	−0.45 (−1.14 to 0.24)	0.20	CC=21	CC=65	1.034 (0.80 to 1.34)	0.80
				CG=78	CG=293
				GG=73	GG=268