Table 3. SNPs previously associated with anthracycline cardiotoxicity (Arms ABC).

Additive effect linear regression analyses in all Arms combined. Logistic regression was performed in those cases (N=17) with congestive heart failure (CHF) versus all other patients. P-values <0.05 are highlighted in bold.

			Linear Max drop in LVEF			Logistic CHF (N=17)
Gene	rs ID	Function	Freq A1 (N=1191)	Beta, L95-U95	P	Freq A1 (N=17)	OR, L95-U95	P
ABCB1	rs2235047	intronic	0.02	−2.34 (−4.28 to −0.40)	0.018	0.00	NA	0.996
SLC28A3	rs7853758	L464L	0.16	−0.11 (−0.84 to 0.62)	0.766	0.12	0.71 (0.25 to 2.02)	0.523
CBR3	rs1056892	V244M	0.35	0.84 (0.26 to 1.41)	0.004	0.35	1.01 (0.49 to 2.08)	0.972
NCF4	rs1883112	5′ flanking	0.44	0.19 (−0.36 to 0.72)	0.492	0.24	0.35 (0.15 to 0.78)	0.011
RAC2	rs13058338	intronic	0.26	0.05 (−0.55 to 0.66)	0.861	0.29	1.21 (0.58 to 2.57)	0.611
RARG	rs2229774	S427L	0.07	0.44 (0.61 to 1.48)	0.412	0.15	2.39 (0.91 to 6.23)	0.076
UGT1A6	rs17863783	V209V	0.02	−1.67 (−3.52 to 0.18)	0.078	0.00	NA	0.996