Table 1.

Ingenuity analysis identified ethanol degradation as the most significantly altered canonical pathway in the placenta with significantly increased risk for metabolic, neurological, and cardiovascular diseases. The most altered physiologic systems were directly related to fetal organ and embryo development.

INGENUITY Pathway Analysis
Top Canonical Pathways	P Value
Ethanol Degradation II	4.01×10−5
Noradrenaline and Adrenaline Degradation	5.09×10−5
Synaptic Long Term Potentiation	6.33×10−5
Top Diseases
Metabolic Disease	1.43×10−2 – 2.14×10−5
Cardiovascular Disease	1.76×10−2 – 2.84×10−5
Neurological Disease	1.79×10−2 – 1.42×10−5
Physiological System Development and Function
Renal and Urological System Development and Function	1.25×10−2 – 1.41×10−4
Auditory and Vestibular System Development and Function	1.79×10−2 – 3.27×10−4
Embryonic Development	1.79×10−2 – 1.13×10−5
Organismal Development	1.79×10−2 – 4.72×10−5
Hair and Skin Development and Function	3.60×10−3 – 1.13×10−5