Table 2. Additional relevant measures existing in the PhenX Toolkit and applicable to the pregnancy domain.

Existing measure		Domain
Birthplace	Subject	Demographics
	Parents
	Grandparents
Cigarette Smoking	Age of first use	Alcohol, Tobacco and Other Substances
	Age of cessation
	Smoking status
	Dependence on cigarettes/nicotine
	Pregnancy status and tobacco use	Tobacco Regulatory Research
	Environmental tobacco smoke exposure	Environmental Exposures
Tobacco[non-cigarette]	Product type	Oral Health
	Use	Tobacco Regulatory Research: Vector
	30-day quantity and frequency	Alcohol, Tobacco and Other Substances
Alcohol	Age of first use	Alcohol, Tobacco and Other Substances
	30-day quantity and frequency
	Maximum drinks in 24 hours
	Lifetime use
	Lifetime abuse and dependence
Substances	Age of first use	Alcohol, Tobacco and Other Substances
	30-day frequency
	Lifetime use
	Lifetime abuse and dependence
	Patterns of use	Substance Abuse and Addiction
	Screening and severity of substance use problems	Assessment of Substance Use and Substance Use Disorders
Reproductive Health	Ovulation history	Cancer
	History of pre-pubertal development	Reproductive Health
	Assessment of pubertal development
	Human papilloma virus vaccine use
	Contraceptive methods
	Sexual history
	Menstrual history
	Reproductive history
	Female reproductive organ surgical procedures
	Testes development
	Male sexual function
	Prostate health
	Difficulty conceiving
	Causes and treatments of known infertility
	Hormonal therapy
	Male reproductive tract birth defects,
Pregnancy	Pregnancy weight gain	Anthropometrics
	Serial pregnancy weight gain
	Mother and baby health	Tobacco Regulatory Research
	High blood pressure during pregnancy	Cardiovascular
Medical History	Personal history of type I and type II Diabetes	Diabetes