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. Author manuscript; available in PMC: 2018 Sep 29.
Published in final edited form as: Eur J Med Chem. 2017 Jun 29;138:407–421. doi: 10.1016/j.ejmech.2017.06.062

Scheme 2.

Scheme 2

Reagents and conditions: (i) Boc2O, NaHCO3, 1,4-dioxane/H2O, 0 °C to rt, 16 h, 74%; (ii) 3,4-difluoroaniline, HATU, DIPEA, DMF, rt, 1 h, 90%; (iii) TFA, DCM, 0 °C to rt, 2 h, 60%; (iv) cycloalkylsulfonyl chloride, Et3N, CH2Cl2, DMAP, 40 °C, 3 h, 23–47%.