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. Author manuscript; available in PMC: 2018 Sep 15.
Published in final edited form as: Acta Biomater. 2017 Jul 12;60:181–189. doi: 10.1016/j.actbio.2017.07.017

Figure 4. Biomaterial-T lymphocyte cross-talk regulates SHED-mediated bone regeneration.

Figure 4

(a) Micro-CT images of SHED encapsulated in alginate hydrogels with different physiomechanical properties, retrieved 8 weeks after subcutaneous implantation in immunocompromised mice. Pan T lymphocytes were isolated and injected into the mice via the tail vein immediately prior to the surgical procedures. (b) Histological analysis (H&E staining) of retrieved specimens after 8 weeks of subcutaneous implantation. (c) Semi-quantitative analysis via micro-CT images (a) showing the bone volume fraction (BV/TV). (d) Semi-quantitative analysis of the amount of bone regeneration from histological slide presented in panel b. B: regenerated bone, #: connective tissue. NS= not significant, *P<0.05, **P<0.01.