. Author manuscript; available in PMC: 2018 Sep 1.

Published in final edited form as: Alcohol Clin Exp Res. 2017 Jul 25;41(9):1541–1550. doi: 10.1111/acer.13442

Table 1.

Mean arterial pressure (MAP), left ventricular developed pressure (LVDP) and maximum rate of left ventricular pressure rise (dP/dt_max) values before (baseline) and 30 min after pretreatment with 4-MP, 3-AT, their combination or vehicle (saline). These rat groups subsequently received ethanol or its vehicle (saline). Values are mean± SEM.

Pretreatment	Group	N	Hemodynamic variable	Baseline	After pretreatment
Saline	Saline	5	MAP (mmHg)	99.7±1.7	103.0±2.7
			LVDP (mmHg)	161.7±5.1	162.3±5.8
			dP/dt_max (mmHg/s)	6870±1032	6647±1066

	Ethanol	6	MAP (mmHg)	101.4±8.1	99.4±5.9
			LVDP (mmHg)	160.3±11.1	160.5±11.2
			dP/dt_max (mmHg/s)	7227±1236	6952±1300

4-MP	Saline	7	MAP (mmHg)	100.1±5.2	95.4±6.1
			LVDP (mmHg)	165.3±7.4	163.2±7.2
			dP/dt_max (mmHg/s)	7182±619	6859±572

	Ethanol	8	MAP (mmHg)	103.4±5.5	100.0±6.3
			LVDP (mmHg)	170.5±8.8	169.45±8.3
			dP/dt_max (mmHg/s)	7051±682	6589±644

3-AT	Saline	6	MAP (mmHg)	102.7±4.6	93.7±6.4
			LVDP (mmHg)	164.9±15.5	147.9±14.3
			dP/dt_max (mmHg/s)	7468±1465	6492±1388

	Ethanol	7	MAP (mmHg)	102.2±3.8	90.9±3.5^*^#
			LVDP (mmHg)	166.3±10.3	156.6±10.2
			dP/dt_max (mmHg/s)	7331±393	6540±355

4-MPAT	Saline	6	MAP (mmHg)	98.6±2.8	84.6±4.4^*^#
			LVDP (mmHg)	167.9±7.1	153.2±8.4
			dP/dt_max (mmHg/s)	7488±515	6735±422

	Ethanol	7	MAP (mmHg)	97.6±4.5	88.2±3.9^*
			LVDP (mmHg)	159.9±7.4	149.7±9.5
			dP/dt_max (mmHg/s)	6908±735	5961±880

p < 0.05 vs. corresponding value in saline-pretreated group;

p < 0.05 vs. corresponding pretreatment (baseline) value.