Table 3.

Simulation results evaluating the bias and MSE of the estimated MTD for Scenarios 1 through 6 assuming an additive dosing scheme (Dosing Scheme 1) and a geometric dosing scheme (Dosing Scheme 2) for a maximum sample size of N = 21.

	Scenario 1		Scenario 2		Scenario 3		Scenario 4		Scenario 5		Scenario 6
Method	Bias	MSE	Bias	MSE	Bias	MSE	Bias	MSE	Bias	MSE	Bias	MSE
Dosing Scheme 1
CRM	−1.4	2	0.2	0.1	−11.9	140.6	1.1	1.1	−0.4	0.2	2.7	7.1
rCRM1	−1.7	2.8	1.1	1.3	−12.3	150.4	0.1	0.02	−0.6	0.3	2.9	8.3
rCRM2	−1.6	2.6	0.8	0.7	−12.6	159.4	0.6	0.4	0	0.002	2.8	8
CRM − ET	−2.8	7.7	1.2	1.4	−17	287.8	−2	4.1	−1.6	2.4	−0.1	0.01
Hybrid − co 3	−1.7	3	0.5	0.2	−11.5	131.9	0.3	0.1	−1	1.1	3.2	10
Hybrid − co 2	−1.2	1.5	0.6	0.3	−12.2	149.7	0.7	0.5	−1.1	1.1	2.2	4.7