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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2017 Mar 1;132:25–30. doi: 10.1016/j.prostaglandins.2017.02.005

Fig. 2.

Fig. 2

Epidermis-type 12-LOX (e12-LOX) and epithelial 12R-LOX oxidizes arachidonic acid (AA) to their respective S and R enantiomers 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HpETE), which are reduced to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE). CYP450 isoenzymes generate both S and R enantiomers of 12-HETE. 12(S)-HETE and 12(R)-HETE are transformed into 12-oxo-5,8,10,14-eicosatetraenoic acid (12-oxo-ETE) by 12-hydroxyeicosanoid dehydrogenase (12-HEDH) and reduced to 12-oxo-6,8,14-eicosatrienoic acid (12-oxo-ETrE) by 12-oxoeicosanoid Δ10-reductase (Δ10-reductase). 12-ketoreductase (12-KR) converts 12-oxo-ETrE to either 12(R)-hydroxy-5,8,14-eicosatrienoic acid (12(R)-HETrE) or 12(S)-12-hydroxy-5,8,14-eicosatrienoic acid (12(S)-HETrE).