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. Author manuscript; available in PMC: 2017 Sep 4.
Published in final edited form as: Nat Cell Biol. 2017 Mar 1;19(2):155–163. doi: 10.1038/ncb3472

Figure 6. Tissue-scale coordination of cellular behaviors during wound repair.

Figure 6

During wound repair the epithelium organizes directional migration and proliferation in overlapping regions moving towards the wound. Migration delivers cells to the wound region and also enhances stratification. Proliferation replenishes cells as well and limits the size of the repair region. Upon inhibition of migration, stratification is dramatically decreased and cell divisions lose their directionality. Moreover, wound repair is delayed compared to a wild type re-epithelialization. In contrast, upon inhibition of proliferation the tissue compensates by increasing the overall size of the repair region. Thickness of bars represents intensity of the behaviors (migration, red; proliferation, yellow).