Table 1.
Questions and results from the questionnaire (translated from German language).
| “I do agree totally” or “[…] mostly” |
p-Values | |||
|---|---|---|---|---|
| All | Physicians | Study nurses | ||
| Trial related | ||||
| There are currently no trials available for our patient cohort | 2 (4%) | 2 (7%) | 0 | 0.351 |
| Important trials could not be established at our center | 13 (29%) | 12 (41%) | 1 (8%) | 0.039 |
| The inclusion and exclusion criteria are to exclusive | 4 (9%) | 3 (10%) | 1 (8%) | 0.843 |
| Concerning the conduction of clinical trials, I am discouraged by legal regulations (German medical law, German medical technology law, German law for radiation protection, etc.) | 10 (23%) | 10 (34%) | 0 | 0.019 |
| We offer several trials with almost identical inclusion and exclusion criteria (that do compete to each other) | 11 (25%) | 8 (28%) | 3 (25%) | 0.865 |
| Patient related | ||||
| Most patients do refuse to participate in clinical trials | 4 (9%) | 1 (3%) | 2 (17%) | 0.139 |
| I want to protect my patient from additional stress that could be caused by participating in clinical trials | 0 | 0 | 0 | n/a |
| Organization related | ||||
| The documentation effort of clinical trials is to large | 32 (73%) | 20 (69%) | 10 (83%) | 0.345 |
| The documentation effort within the daily clinical routine hampers me to recruit patients to clinical trials | 22 (50%) | 14 (48%) | 7 (58%) | 0.558 |
| There are not enough human resources to conduct (more) clinical trials | 31 (70%) | 20 (69%) | 8 (67%) | 0.886 |
| Technical resources or software solutions for the conduction of clinical trials are lacking | 23 (52%) | 15 (52%) | 7 (58%) | 0.699 |
| Structural shortcomings (technical and/or human resources) already resulted in a refusal from sponsors to initiate a trial at our center | 5 (11%) | 4 (14%) | 1 (8%) | 0.627 |
| Within the last years, trials could not be initiated due to administrative hurdles | 10 (23%) | 7 (24%) | 2 (17%) | 0.599 |
| We do not have enough collaborators to conduct clinical trials | 5 (11%) | 4 (14%) | 0 | 0.176 |
| Conflicts within our center do negatively interfere with our recruiting activity | 6 (14%) | 3 (10%) | 2 (17%) | 0.574 |
| I am not experienced enough yet to conduct clinical trials | 2 (4%) | 1 (3%) | 1 (8%) | 0.509 |
The results represent the complete or predominant agreement to the given statements. The frequency of the answers from physicians and study nurses were compared with the χ2 test.