Table 4.
Amino acid level changes in time in good outcome SAH patients with (GO-SAH).
| Monitored parameter | Days 0–3 post-SAH | Day 5 post-SAH | Day 10 post-SAH | Omnibus test p value | Days 0–3 vs Day 5 p value post hoc | Days 0–3 vs Day 10 p value post hoc | Day 5 vs Day 10 p value post hoc |
|---|---|---|---|---|---|---|---|
| C-reactive protein (mg/L) | 125.00 | 50.70 | 27.00 | 0.049 | 0.345 | 0.012 | 0.073 |
| White blood cell count (106/mm3) | 9.86 | 10.57 | 9.34 | 0.631 | |||
| Haemoglobin (g/dL) | 12.10 | 10.60 | 10.50 | 0.066 | |||
| Temperature (°C) | 37.00 | 37.30 | 36.90 | 0.382 | |||
| Fibrinogen (mg/dL) | 485.00 | 442.00 | 423.00 | 0.327 | |||
| O-phosphoethanolamine (μM) | 6.20 | 5.00 | 5.80 | 0.325 | |||
| Taurine (μM) | 13.90 | 14.60 | 10.80 | 0.867 | |||
| Asparagine (μM) | 8.40 | 18.30 | 21.20 | 0.180 | |||
| Serine (μM) | 45.10 | 73.80 | 76.10 | 0.031 | 0.039 | 0.013 | 0.566 |
| Glycine (μM) | 29.60 | 32.60 | 42.50 | 0.565 | |||
| Hydroxyproline (μM) | 0.70 | 1.10 | 1.40 | 0.094 | |||
| Ethylaminev (μM) | 5.70 | 10.10 | 9.80 | 0.039 | 0.078 | <0.01 | 0.187 |
| Glutamine (μM) | 454.30 | 818.70 | 828.30 | 0.001 | <0.01 | <0.001 | 0.565 |
| Aspartic acid (μM) | 0.70 | 0.40 | 1.20 | 0.215 | |||
| Citruline (μM) | 1.90 | 2.40 | 2.80 | 0.069 | |||
| Threonine (μM) | 22.90 | 52.50 | 61.20 | 0.012 | 0.128 | <0.01 | <0.01 |
| Beta-alanine (μM) | 28.30 | 26.80 | 26.70 | 0.553 | |||
| Alanine (μM) | 70.70 | 106.20 | 120.30 | 0.124 | |||
| Glutamic acid (μM) | 4.50 | 2.70 | 2.10 | 0.898 | |||
| Histidine (μM) | 16.80 | 38.10 | 37.40 | 0.156 | |||
| 3-Methylhistidine (μM) | 0.60 | 1.50 | 0.90 | 0.369 | |||
| 2-Aminoadipic acid (μM) | 1.30 | 1.50 | 1.30 | 0.129 | |||
| Gamma-aminobutyric acid (μM) | 0.30 | 0.20 | 0.50 | 0.633 | |||
| 3-Aminoisobutyric acid (μM) | 0.20 | 0.30 | 0.30 | 0.215 | |||
| 2-Aminobutyric acid (μM) | 4.60 | 11.40 | 11.40 | 0.010 | 0.019 | <0.01 | 0.427 |
| Arginine (μM) | 18.50 | 26.50 | 24.10 | 0.050 | 0.073 | 0.012 | 0.345 |
| Proline (μM) | 3.40 | 11.90 | 15.20 | 0.062 | |||
| Ornithine (μM) | 7.60 | 17.30 | 14.30 | 0.368 | |||
| Cystathionine (μM) | 1.00 | 1.00 | 1.20 | 0.648 | |||
| Cysteine (μM) | 1.60 | 1.70 | 2.10 | 0.368 | |||
| Lysine (μM) | 43.00 | 83.20 | 70.80 | 0.017 | 0.017 | <0.01 | 0.735 |
| Methionine (μM) | 4.60 | 10.00 | 11.90 | 0.008 | 0.029 | <0.01 | 0.200 |
| Valine (μM) | 28.20 | 61.60 | 78.10 | 0.015 | 0.017 | <0.01 | 0.683 |
| Tyrosine (μM) | 23.00 | 35.10 | 28.50 | 0.020 | 0.023 | <0.01 | 0.647 |
| Isoleucine (μM) | 5.90 | 11.10 | 13.60 | 0.024 | 0.081 | <0.01 | 0.219 |
| Leucine (μM) | 22.60 | 39.70 | 60.50 | 0.024 | 0.022 | 0.013 | 0.801 |
| Phenylalanine (μM) | 20.90 | 35.20 | 37.50 | 0.038 | 0.040 | 0.018 | 0.700 |
| Tryptophan (μM) | 8.00 | 11.80 | 11.10 | 0.072 |
Median levels of the amino acids are presented in the table. Omnibus statistical test (Friedman or repeated measures ANOVA) revealed significant changes in concentration of 13 amino acids (shown in bold). Next, post hoc analysis (Conover–Iman for Friedman test and Fisher for repeated measures ANOVA) was run for those 13 amino acids to specify between what time points (days 0–3, 5, or 10 post-SAH) the differences in concentration were significant (shown in bold).