Table 2.
Splenic cell subsets in SIRT2+/+ and SIRT2−/− mice.
| Cell subset | SIRT2+/+ | SIRT2−/− |
|---|---|---|
| CD3+ T cells (%) | 27.3 ± 4.6 | 36.3 ± 4.8 |
| CD4+ | 62.3 ± 2.7 | 61.5 ± 4.3 |
| CD4+ CD44low CD62Lhigh (naive) | 46.0 ± 2.9 | 43.7 ± 6.8 |
| CD4+ CD44high CD62Llow (memory) | 16.3 ± 2.9 | 17.8 ± 6.9 |
| CD8+ | 31.5 ± 2.0 | 32.0 ± 2.9 |
| CD8+ CD44low CD62Lhigh (naive) | 23.1 ± 0.5 | 23.5 ± 0.3 |
| CD8+ CD44high CD62Llow (memory) | 8.4 ± 0.5 | 8.5 ± 0.3 |
| CD4− CD8− | 1.3 ± 0.2 | 1.6 ± 0.2 |
| B220+ B cells (%) | 52.2 ± 7.4 | 51.3 ± 3.1 |
| B220+ IgD+ CD23+ (mature) | 45.6 ± 1.2 | 44.1 ± 0.9 |
| B220+, non-IgD+/CD23+ (immature) | 6.6 ± 1.2 | 7.2 ± 0.9 |
| CD11c+ dendritic cells (%) | 6.6 ± 0.2 | 6.4 ± 0.6 |
| B220− | 62.8 ± 2.5 | 62.8 ± 4.7 |
| B220+ | 37.2 ± 2.5 | 37.2 ± 4.7 |
| CD4+ CD25+ Foxp3+ Tregs (%) | 4.5 ± 0.4 | 4.7 ± 0.2 |
Data are means ± SD of four animals per group expressed as the percentage of CD3+, B220+, CD11c+, and CD4+ Foxp3+ splenic cells or the percentage of the CD3+, B220+, and CD11c+ parental populations expressing CD4, CD8, CD44, CD62L, IgD, and CD23. Total cell numbers were 74.2 ± 5.6 and 67.4 ± 8.7 millions per spleen in SIRT2+/+ and SIRT2−/− mice, respectively. No statistically significant differences in subset percentages or absolute numbers were detected.