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. 2017 Sep 1;8:401. doi: 10.1038/s41467-017-00518-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Rab7-dependent LE sorting is involved in LTD. a Confocal images of a cerebellar slice double stained with antibodies against calbindin (green) and Rab7 (red). Scale bars: top, 40 μm; bottom, 4 μm. The area within the white square is magnified in the lower panels. b Images of a cerebellar slice expressing GFP-Rab7TN in PCs. Scale bars: top, 300 μm; bottom, 50 μm. c Amplitudes of PF-EPSCs elicited by PF stimuli of increasing intensity (8.2, 17.4, 26.5, 35.6, 44.9, 54.2, and 63.6 μA), which were recorded from PCs expressing GFP alone (green circles, n = 10), or GFP-Rab7TN (orange circles, n = 6). d Paired pulse facilitation (PPF) ratios of PF-EPSCs elicited by a pair of PF stimuli with different intervals (50–400 ms) from PCs expressing GFP alone (green circles, n = 13), or GFP-Rab7TN (orange circles, n = 12). e Time course of LTD induced by PFΔV in PCs expressing GFP alone (green circles, n = 9), or GFP-Rab7TN (orange circles, n = 8). Averaged traces of PF-EPSCs recorded before (baseline) and after PFΔV (LTD) are shown in the inset. Calibration: 100 pA, 30 ms. PF-EPSC amplitudes shown here as well as in the subsequent figures presenting the time course of PF-EPSCs are normalized to their mean prestimulation level. n.s., not significant. Exact P values for the data sets in this figure are provided in Supplementary Table 2