Figure 10.

Type I interferon is required for control of blood bacterial burden following infection with intermediate virulent and virulent Streptococcus suis serotype 2 strains. Blood bacterial burden of wild-type and IFNAR^−/− mice infected with the different S. suis strains 12 h post-infection (p.i.) (A) or 48 h p.i. (B). Data represent the geometric mean (n = 15). A blood bacterial burden of 2 × 10⁹ CFU/mL, corresponding to the average burden upon euthanasia, was attributed to euthanized mice. * (p < 0.05) and ** (p < 0.01) indicate a significant difference between blood bacterial burden of wild-type and IFNAR^−/− mice.