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. 2017 Aug 28;8:1039. doi: 10.3389/fimmu.2017.01039

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Copyright © 2017 Auger, Santinón, Roy, Mossman, Xu, Segura and Gottschalk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The interferon regulatory factors (IRFs) 1, 3, and 7 are involved in interferon (IFN)-β expression by dendritic cells (DCs) following infection with Streptococcus suis. S. suis-induced IRF1, IRF3, and IRF7 mRNA expression by DCs 6 h following infection with the different strains (A). IFN-β mRNA expression induced by the different S. suis strains following infection of IRF1^−/−, IRF3^−/−, or IRF7^−/− DCs in comparison with cells from wild-type mice (B). Data represent the mean ± SEM (n = 4). ** (p < 0.01) indicates a significant difference between expression by wild-type and deficient DCs.