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. 2017 Aug 28;8:1039. doi: 10.3389/fimmu.2017.01039

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Copyright © 2017 Auger, Santinón, Roy, Mossman, Xu, Segura and Gottschalk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type I interferon modulates plasma pro-inflammatory cytokines involved in Streptococcus suis-induced systemic inflammation. Plasma levels of tumor necrosis factor (A), interleukin (IL)-6 (B), IL-12p70 (C), CCL2 (D), CCL3 (E), and CXCL1 (F) in wild-type and IFNAR^−/− mice 12 h following infection with the different S. suis strains. Data represent the mean ± SEM (n = 8). * (p < 0.05), ** (p < 0.01), and *** (p < 0.001) indicate a significant difference in plasma levels between wild-type and IFNAR^−/− mice.