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Extracellular 2N4R tau oligomers disrupt endogenous wild-type tau. A, B) Extracelluar 2N4R oligomers, but not monomers or fibrils, disrupt endogenous tau, as visualized by Tau 5 staining. C–F) No disruption of MAP2 or BIII tubulin was observed after treatment of neurons with monomeric, oligomeric or fibrillar 2N4R tau. Error bars represent SEM.
