Fig. 7.

Extracellular oligomers of mixed isoform composition cause endogenous tau aggregation. A) Neurons treated with oligomers, but not monomers or fibrils, of a 1:1 mixture of 2N3R and 2N4R tau caused aggregation of endogenous axonal tau. B) Neurons exposed to an equimolar mix of all 6 tau isoforms developed endogenous tau aggregates, especially when the extracellular tau was oligomeric. Treatment with oligomers of all 6 isoforms additionally caused extensive aggregation of MAP2. Error bars represent SEM.