Table 5.

Differentially enriched gene sets in papillary thyroid cancer associated with mortality.

Gene sets	DETAILS	No. Members in Gene Set	No. Members in Leading Edge(%)	NES*	FDR** q-val	FWER# p-val
AMINOACYL_TRNA _BIOSYNTHESIS	Gene set involved in Aminoacyl-tRNA biosynthesis	23	14 (61%) 1	−2.03	0.003	0.003
HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Gene set involved in Aminoacyl-tRNA biosynthesis	31	18 (58%)	−2.00	0.007	0.01
MITOCHONDRIA	Large gene set involved in oxygen transport, ATP metabolism, glycolysis	391	214 (55%)	−1.94	0.016	0.04
TRNA_SYNTHETASES	Gene set involved in Aminoacyl-tRNA biosynthesis	19	12 (63%)	−1.92	0.020	0.06
PORPHYRIN_AND_CHLOROPHYLL_MET ABOLISM	Gene set involved in heme, porphyrin and chlorophyll metabolism	20	12 (60%)	−1.91	0.017	0.06
HUMAN_MITODB_6_2002	A set of genes involved in oxidative phosphorylation decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity.	382	229 (60%)	−1.88	0.026	0.09
ZELLER_MY C_UP	genes that are up-regulated, or responsive, to Myc.	23	10 (43%)	−1.86	0.030	0.11
FATTY_ACID_SYNT HESIS	Genes involved in fatty acid synthesis	16	11 (69%)	−1.84	0.037	0.16
HSA00190_OXIDATIVE_PHO SPHORYLATION	Gene set involved in oxygen transport, ATP metabolism, glycolysis	113	83 (73%)	−1.83	0.038	0.18
SMITH_HCV_INDUC ED_HCC_UP	Potential marker genes specifically up-regulated in the majority of hepatocellular carcinoma (HCC) tumors.	33	20 (61%)	−1.80	0.046	0.25
CANCERDRUGS_PROBCELL_DN	Down-regulated by at least two of four cancer drugs (cisplatin, camptothecin, methotrexate and/or paclitaxel) in pro-B cells	15	11 (73%)	−1.81	0.048	0.25

^*NES: normalized enriched score,

^**FDR: false discovery rate,

^#FWER: family wise error rate