Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 2;18:165. doi: 10.1186/s12931-017-0651-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 2 — Extracellular histones were detected in the BALF of ARDS patients and their possible sources. Extracellular histones were also significantly higher in the BALF of ARDS patients than in healthy controls. Likewise, severe ARDS patients had higher BALF extracellular histone levels than moderate or mild patients, whereas non-survivor ARDS patients had higher BALF extracellular histone levels than survivors. Quantification of BALF LDH activity, a marker reflecting tissue damage, and BALF MPO activity, a marker of inflammatory cell activation, showed that both LDH and MPO levels were increased remarkably in ARDS patients compared to healthy controls, thus indicating a possible cellular sources for extracellular histones. Variables were expressed as median (interquartile range)